白皮杉醇酸 F-J，五种从. 中分离得到的新型羊毛甾烷型三萜
Piptolinic acids F-J, five new lanostane-type triterpenoids from .
机构信息
The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi , China.
University of Chinese Academy of Sciences , Beijing , China.
出版信息
Nat Prod Res. 2019 Nov;33(21):3044-3051. doi: 10.1080/14786419.2018.1516218. Epub 2018 Oct 26.
Five new lanostane-type triterpenoids, named piptolinic acids F - J (-), as well as seven known analogues (-), were isolated from methanolic extract of the fruiting bodies of . Compounds - were 24-methyl-lanostane triterpenoids, while compound was a 3,4--lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC = 42.8 μM) and human renal carcinoma cell line 786-O (IC = 56.5 μM).
从药用真菌 的子实体甲醇提取物中分离得到五个新的羊毛甾烷型三萜类化合物，命名为 pip 托林酸 F−J(-)，以及七个已知类似物(-)。化合物(-)为 24-甲基羊毛甾烷三萜类化合物，而化合物 为 3,4--羊毛甾烷衍生物。它们的结构是基于广泛的光谱分析（1D、2D NMR 和 HRESIMS）确定的。细胞毒性评价表明，化合物 对人黑色素瘤细胞系 A-375（IC=42.8 μM）和人肾癌细胞系 786-O（IC=56.5 μM）表现出中等的细胞毒性活性。
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