Zou Z-C, -J Mao L, Shi Y-Y, Chen J-H, Wang L-S, Cai W
Department of Nutrition, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Eur Rev Med Pharmacol Sci. 2015 Dec;19(23):4569-75.
Aim of this study was to investigate the association of the FTO rs9939609 polymorphism with the effects of the exercise and dietary intervention on obese adolescents and children in China.
Total 138 chinese children and adolescents (77 males and 61 females, aged 10-18 years) were recruited in the 2012 summer camp in Shanghai. Dietary and exercise intervention was performed for four weeks. Obesity related parameters were detected by the physical examination before and after four-week's intervention. Genotyping of the FTO rs9939609 was performed by using a TaqMan SNP Genotyping Assay. SPSS 19.0 were used to do the statistical analysis.
Finally, 135 campers were investigated in this study. The AA, AT and TT genotype frequencies of rs9939609 were 5.2%, 33.3% and 61.5%, respectively. The BMI in individuals with the genotype AA (or AT) was significantly higher compared with their with TT genotype (p = 0.044). The levels of body mass index (BMI), insulin (INS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), red blood cell (RBC), Hemoglobin (HB) and hematocrit (HCT) in campers were significantly declined by the combined intervention (p < 0.05). Moreover, the levels of TC, low-density lipoprotein (LDL), RBC, HB, and HCT in the camper with genotype AA (or AT) were significantly decreased by the combined intervention compared with the camper with genotype TT (p < 0.05).
The effects of exercise combined with dietary intervention on obesity were associated with the FTO rs9939609 polymorphism in chinese adolescents and children.
本研究旨在探讨FTO rs9939609基因多态性与运动及饮食干预对中国肥胖青少年和儿童影响之间的关联。
2012年上海夏令营招募了138名中国儿童和青少年（77名男性，61名女性，年龄10 - 18岁）。进行了为期四周的饮食和运动干预。四周干预前后通过体格检查检测肥胖相关参数。采用TaqMan SNP基因分型检测法对FTO rs9939609进行基因分型。使用SPSS 19.0进行统计分析。
本研究最终纳入135名营员。rs9939609的AA、AT和TT基因型频率分别为5.2%、33.3%和61.5%。AA（或AT）基因型个体的BMI显著高于TT基因型个体（p = 0.044）。联合干预使营员的体重指数（BMI）、胰岛素（INS）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、红细胞（RBC）、血红蛋白（HB）和血细胞比容（HCT）水平显著下降（p < 0.05）。此外，与TT基因型营员相比，联合干预使AA（或AT）基因型营员的TC、低密度脂蛋白（LDL）、RBC、HB和HCT水平显著降低（p < 0.05）。
运动与饮食联合干预对肥胖的影响与中国青少年和儿童的FTO rs9939609基因多态性有关。
