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J Infect Dis. 2016 May 1;213(9):1359-61. doi: 10.1093/infdis/jiv474. Epub 2015 Sep 27.
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Dual-Use Research of Concern (DURC) Review at American Society for Microbiology Journals.美国微生物学会期刊的两用关注研究（DURC）审查。
mBio. 2015 Aug 11;6(4):e01236. doi: 10.1128/mBio.01236-15.
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Influenza gain-of-function experiments: their role in vaccine virus recommendation and pandemic preparedness.流感功能获得性实验：它们在疫苗病毒推荐和大流行防范中的作用。
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The Irrationality of GOF Avian Influenza Virus Research.高致病性禽流感病毒研究的不合理性。
Front Public Health. 2014 Jul 16;2:77. doi: 10.3389/fpubh.2014.00077. eCollection 2014.
7
Regulating dual-use research in Europe.欧洲两用研究的监管
Science. 2014 Jan 24;343(6169):368-9. doi: 10.1126/science.343.6169.368-b.
8
The changing burden of infectious disease in Europe.欧洲传染病负担的变化。
Sci Transl Med. 2011 Oct 5;3(103):103cm30. doi: 10.1126/scitranslmed.3002556.

欧洲科学院就流感病毒研究中的功能获得性研究提供建议。

European Academies Advise on Gain-of-Function Studies in Influenza Virus Research.

作者信息

Fears Robin, ter Meulen Volker

机构信息

Biosciences Programme, EASAC, German National Academy of Sciences, Halle (Saale), Germany Gain of Function Working Group, EASAC, German National Academy of Sciences, Halle (Saale), Germany.

Biosciences Steering Panel, EASAC, German National Academy of Sciences, Halle (Saale), Germany Gain of Function Working Group, EASAC, German National Academy of Sciences, Halle (Saale), Germany

出版信息

J Virol. 2015 Dec 23;90(5):2162-4. doi: 10.1128/JVI.03045-15.

DOI:10.1128/JVI.03045-15
PMID:26699646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4810713/
Abstract

Gain-of-function (GoF) studies to understand factors affecting transmissibility of potentially pandemic pathogens are controversial. The European Academies Science Advisory Council (EASAC) recently published consensus recommendations relating to GoF research review and management on self-regulation and harmonization; bioethical considerations; benefit-risk assessment; biosafety, and biosecurity advisory options; and publication of sensitive information. A layered approach to integration of responsibilities must include conforming to the stringent rules and guidance already existing. Further commitment is essential to extend the debate on issues worldwide.

摘要

为了解影响潜在大流行病原体传播性的因素而进行的功能获得（GoF）研究存在争议。欧洲科学院科学咨询委员会（EASAC）最近发布了关于GoF研究审查和管理的共识建议，内容涉及自我监管与协调；生物伦理考量；利弊评估；生物安全和生物安保咨询选项；以及敏感信息的发布。整合责任的分层方法必须包括遵守现有的严格规则和指导方针。进一步致力于在全球范围内就这些问题展开辩论至关重要。