久坐不动的中年男性在次最大运动至疲劳过程中血浆白细胞介素-6及其可溶性受体的反应。
Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men.
作者信息
Gray S R, Robinson M, Nimmo M A
机构信息
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
出版信息
Cell Stress Chaperones. 2008 Summer;13(2):247-51. doi: 10.1007/s12192-008-0019-3. Epub 2008 Mar 5.
Abstract
The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
摘要
多效细胞因子白细胞介素-6（IL-6）已被证明在运动过程中会增加。关于可溶性IL-6受体（sIL-6R和sgp130）在这种运动中的反应知之甚少。本研究的目的是调查人体在疲劳性次最大运动期间血浆IL-6、sIL-6R和sgp130的反应。12名参与者进行了递增运动测试直至力竭，一周后进行了一次次最大运动（乳酸阈值的96±6%）直至自愿力竭。在休息时和运动后立即采集血样，分析其中的IL-6、sIL-6R和sgp130。运动期间IL-6增加了（P<0.01）8.4±8.9 pg ml-1（75.7%）。sIL-6R和sgp130也分别增加了（P<0.05）2.7±3.9 ng ml-1（9.6%）和37.7±55.6 ng ml-1（9.6%）。本研究是首次证明除IL-6外，急性运动应激会导致sIL-6R和sgp130均增加的调查。
相似文献
1
Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men.久坐不动的中年男性在次最大运动至疲劳过程中血浆白细胞介素-6及其可溶性受体的反应。
Cell Stress Chaperones. 2008 Summer;13(2):247-51. doi: 10.1007/s12192-008-0019-3. Epub 2008 Mar 5.
2
Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.慢性疲劳综合征患者静息和运动时的血浆白细胞介素-6、其可溶性受体和 F2-异前列腺素。
Scand J Med Sci Sports. 2010 Apr;20(2):282-90. doi: 10.1111/j.1600-0838.2009.00895.x. Epub 2009 Apr 13.
3
The reliability of the IL-6, sIL-6R and sgp130 response to a preloaded time trial.IL-6、sIL-6R 和 sgp130 对预加载时间试验的反应的可靠性。
Eur J Appl Physiol. 2010 Oct;110(3):619-25. doi: 10.1007/s00421-010-1548-x. Epub 2010 Jun 24.
4
Increased levels of IL-6, sIL-6R, and sgp130 in the aqueous humor and serum of patients with diabetic retinopathy.糖尿病视网膜病变患者房水和血清中白细胞介素-6、可溶性白细胞介素-6受体和可溶性糖蛋白130水平升高。
Mol Vis. 2016 Aug 9;22:1005-14. eCollection 2016.
5
Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa.神经性厌食症女性患者中循环白细胞介素6及其受体的可溶性形式与静息能量消耗的关系
Clin Endocrinol (Oxf). 2013 Dec;79(6):812-6. doi: 10.1111/cen.12118. Epub 2013 May 6.
6
The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes.白细胞介素 6 中和的 sIL-6R-sgp130 缓冲系统在 2 型糖尿病患者中受到干扰。
Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E411-E420. doi: 10.1152/ajpendo.00166.2019. Epub 2019 Jun 25.
7
The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response.运动对血浆可溶性白细胞介素-6 受体浓度的影响：二分反应。
Exerc Immunol Rev. 2010;16:56-76.
8
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.白细胞介素 (IL)-6、IL-6·可溶性 IL-6 受体 (sIL-6R) 和 IL-6·sIL-6R·sgp130 复合物的平衡允许经典信号和转导信号同时发生。
J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163. Epub 2018 Mar 20.
9
Serum levels of IL-6 type cytokines and soluble IL-6 receptors in active B-cell chronic lymphocytic leukemia and in cladribine induced remission.活动性B细胞慢性淋巴细胞白血病及克拉屈滨诱导缓解期的血清IL-6型细胞因子和可溶性IL-6受体水平
Mediators Inflamm. 1999;8(6):277-86. doi: 10.1080/09629359990289.
10
Measurements of IL-6, soluble IL-6 receptor and soluble gp130 in sera of B-cell lymphoma patients. Does viscum album treatment affect these parameters?B细胞淋巴瘤患者血清中白细胞介素-6、可溶性白细胞介素-6受体和可溶性糖蛋白130的检测。槲寄生治疗是否会影响这些参数？
Biomed Pharmacother. 2002 May;56(3):152-8. doi: 10.1016/s0753-3322(02)00165-8.
引用本文的文献
1
Interplay between physical activity, inflammation, and cognitive performance in women with type 2 diabetes: an observational study focused on IL-6 pathway mediators.2型糖尿病女性身体活动、炎症与认知表现之间的相互作用：一项聚焦于IL-6通路介质的观察性研究
Diabetol Metab Syndr. 2025 Aug 12;17(1):327. doi: 10.1186/s13098-025-01908-0.
2
IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance.白细胞介素-6 信号在急性运动和慢性训练中的作用：对健康和运动表现的潜在影响。
Scand J Med Sci Sports. 2023 Jan;33(1):4-19. doi: 10.1111/sms.14241. Epub 2022 Oct 8.
3
Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners.可溶性白细胞介素-6受体调节长跑运动员中白细胞介素-6依赖的血管重塑
Front Physiol. 2021 Oct 11;12:722528. doi: 10.3389/fphys.2021.722528. eCollection 2021.
4
Role of Interleukin-6 in Vascular Health and Disease.白细胞介素-6在血管健康与疾病中的作用。
Front Mol Biosci. 2021 Mar 16;8:641734. doi: 10.3389/fmolb.2021.641734. eCollection 2021.
5
A Bioinformatics Model of Human Diseases on the Basis of Differentially Expressed Genes (of Domestic Versus Wild Animals) That Are Orthologs of Human Genes Associated with Reproductive-Potential Changes.基于差异表达基因（家养动物与野生动物的基因）的人类疾病的生物信息学模型，这些基因是与生殖潜能变化相关的人类基因的同源基因。
Int J Mol Sci. 2021 Feb 26;22(5):2346. doi: 10.3390/ijms22052346.
6
Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers.儿童幼年特发性关节炎单次运动：对炎症标志物的影响。
Mediators Inflamm. 2018 Jun 13;2018:9365745. doi: 10.1155/2018/9365745. eCollection 2018.
7
An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men.低容量高强度间歇训练（HIIT）对超重和肥胖男性降低健康风险的评估。
BMC Obes. 2017 Apr 19;4:17. doi: 10.1186/s40608-017-0151-7. eCollection 2017.
8
Heat stress, gastrointestinal permeability and interleukin-6 signaling - Implications for exercise performance and fatigue.热应激、胃肠道通透性与白细胞介素-6信号传导——对运动表现和疲劳的影响
Temperature (Austin). 2016 Apr 28;3(2):240-251. doi: 10.1080/23328940.2016.1179380. eCollection 2016 Apr-Jun.
9
IL-6 Transsignaling in Patients with Chronic Spontaneous Urticaria.慢性自发性荨麻疹患者中的白细胞介素-6转信号传导
PLoS One. 2015 Dec 23;10(12):e0145751. doi: 10.1371/journal.pone.0145751. eCollection 2015.
10
A neuroinflammatory model for acute fatigue during exercise.运动性急性疲劳的神经炎症模型。
Sports Med. 2014 Nov;44(11):1479-87. doi: 10.1007/s40279-014-0232-4.
本文引用的文献
1
Physiological roles of muscle-derived interleukin-6 in response to exercise.肌肉来源的白细胞介素-6在运动反应中的生理作用。
Curr Opin Clin Nutr Metab Care. 2007 May;10(3):265-71. doi: 10.1097/MCO.0b013e3280ebb5b3.
2
IL-6 increases muscle insulin sensitivity only at superphysiological levels.白细胞介素-6仅在超生理水平时才会增加肌肉对胰岛素的敏感性。
Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1842-6. doi: 10.1152/ajpendo.00701.2006. Epub 2007 Feb 27.
3
Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women.超重女性进行一年中等强度抗阻训练后炎症生物标志物的变化。
Int J Obes (Lond). 2007 Jun;31(6):996-1003. doi: 10.1038/sj.ijo.0803534. Epub 2007 Feb 13.
4
The effects of exercise on perceived stress and IL-6 levels among older adults.运动对老年人感知压力和白细胞介素-6水平的影响。
Biol Res Nurs. 2007 Jan;8(3):186-94. doi: 10.1177/1099800406295990.
5
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase.白细胞介素-6通过AMP激活的蛋白激酶增加人体中胰岛素刺激的葡萄糖代谢以及体外葡萄糖摄取和脂肪酸氧化。
Diabetes. 2006 Oct;55(10):2688-97. doi: 10.2337/db05-1404.
6
Sleep enhances IL-6 trans-signaling in humans.睡眠可增强人类体内白细胞介素-6的转信号传导。
FASEB J. 2006 Oct;20(12):2174-6. doi: 10.1096/fj.06-5754fje. Epub 2006 Aug 15.
7
Human resting extracellular heat shock protein 72 concentration decreases during the initial adaptation to exercise in a hot, humid environment.在炎热潮湿环境中开始适应运动的过程中，人体静息状态下细胞外热休克蛋白72的浓度会降低。
Cell Stress Chaperones. 2006 Summer;11(2):129-34. doi: 10.1379/csc-158r.1.
8
Interleukin-6 trans-signalling in chronic inflammation and cancer.白细胞介素-6在慢性炎症和癌症中的转信号传导
Scand J Immunol. 2006 May;63(5):321-9. doi: 10.1111/j.1365-3083.2006.01750.x.
9
Directing transition from innate to acquired immunity: defining a role for IL-6.引导从先天免疫到获得性免疫的转变：确定白细胞介素-6的作用。
J Immunol. 2005 Sep 15;175(6):3463-8. doi: 10.4049/jimmunol.175.6.3463.
10
Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle.运动、训练和糖原可用性对人骨骼肌中白细胞介素-6受体表达的影响。
J Appl Physiol (1985). 2005 Dec;99(6):2075-9. doi: 10.1152/japplphysiol.00590.2005. Epub 2005 Aug 11.
Zotero 插件