Linderkamp O, Holthausen H, Seifert J, Butenandt I, Riegel K P
Eur J Pediatr. 1977 Jun 1;125(2):143-51. doi: 10.1007/BF00489987.
Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes or more in 5 children, indicating the existence of slowly circulating red cells. Mixing of labelled albumin was complete within 10 minutes in 15 patients and within 20 minutes in all the children studied. In a burned patient with severe sepsis, exchange transfusion improved the clinical state and normalized the equilibration pattern of labelled red cells. The mean body/venous haematocrit ratio was 0.893+/-0.018 (SD) in the children with sepsis, 0.859+/-0.052 in the burned patients, and 0.916+/-0.078 in the children with acute lymphoblastic leukaemia, increasing with spleen size in the latter group.
采用51铬标记红细胞和125碘人血清白蛋白对5例脓毒症患儿、6例烧伤患儿和7例急性淋巴细胞白血病患儿进行血容量估计。平衡模式研究表明，5例患儿标记红细胞的混合时间延长至40分钟或更长，表明存在缓慢循环的红细胞。15例患者标记白蛋白在10分钟内混合完成，所有研究患儿在20分钟内混合完成。在1例严重脓毒症烧伤患者中，换血改善了临床状态，并使标记红细胞的平衡模式恢复正常。脓毒症患儿的平均体静脉血细胞比容比值为0.893±0.018（标准差），烧伤患者为0.859±0.052，急性淋巴细胞白血病患儿为0.916±0.078，后一组随脾脏大小增加。
