Crowe William, Doherty Leanne, Watson Gene, Armstrong David, Ball Elisabeth, Magee Pamela, Allsopp Philip, Bell Aubrey, Strain J J, McSorley Emeir
Northern Ireland Centre for Food & Health (NICHE), University of Ulster, Coleraine BT52 1SA, Northern Ireland.
Departments of Dentistry, Environmental Medicine, and Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Int J Environ Res Public Health. 2015 Dec 23;13(1):ijerph13010075. doi: 10.3390/ijerph13010075.
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, and environmental factors are proposed to exacerbate existing symptoms. One such environmental factor is mercury. The aim of this study was to investigate the relationship between exposure to mercury (Hg) and disease activity and disease associated damage in Total Hg concentrations in hair and urine were measured in 52 SLE patients. Dental amalgams were quantified. Disease activity was assessed using three indexes including the British Isles Lupus Assessment Group Index (BILAG). Disease associated damage was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology SLICC/ACR Damage Index. Pearson's correlation identified a significant negative correlation between hair Hg and BILAG (r = -0.323, p = 0.029) and SLICC/ACR (r = -0.377, p = 0.038). Multiple regression analysis identified hair Hg as a significant predictor of disease associated damage as determined by SLICC/ACR (β = -0.366, 95% confidence interval (CI): -1.769, -0.155 p = 0.019). Urinary Hg was not related to disease activity or damage. Fish consumption is the primary route of MeHg exposure in humans and the inverse association of hair Hg with disease activity observed here might be explained by the anti-inflammatory effects of n-3 long chain polyunsaturated fatty acids also found in fish.
系统性红斑狼疮（SLE）是一种自身免疫性炎症性疾病，环境因素被认为会加剧现有的症状。汞就是这样一种环境因素。本研究的目的是调查汞暴露与疾病活动及疾病相关损害之间的关系。对52例SLE患者测量了头发和尿液中的总汞浓度。对牙科汞合金进行了定量分析。使用包括不列颠群岛狼疮评估组指数（BILAG）在内的三个指标评估疾病活动。使用系统性红斑狼疮国际协作临床/美国风湿病学会SLICC/ACR损害指数测量疾病相关损害。Pearson相关性分析确定头发汞与BILAG（r = -0.323，p = 0.029）和SLICC/ACR（r = -0.377，p = 0.038）之间存在显著负相关。多元回归分析确定头发汞是SLICC/ACR所确定的疾病相关损害的显著预测因子（β = -0.366，95%置信区间（CI）：-1.769，-0.155，p = 0.019）。尿汞与疾病活动或损害无关。鱼类消费是人类甲基汞暴露的主要途径，此处观察到的头发汞与疾病活动的负相关可能由鱼类中也含有的n-3长链多不饱和脂肪酸的抗炎作用来解释。
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