Gustafsson Hanna C, Kuzava Sierra E, Werner Elizabeth A, Monk Catherine
Department of Psychiatry/Division of Behavioral Medicine, Columbia University Medical Center, New York, NY, 10032.
New York State Psychiatric Institute, New York, NY.
Dev Psychobiol. 2016 May;58(4):528-35. doi: 10.1002/dev.21391. Epub 2015 Dec 28.
Research with rodents and nonhuman primates suggests that maternal prenatal dietary fat intake is associated with offspring behavioral functioning indicative of risk for psychopathology. The extent to which these findings extend to humans remains unknown. The current study administered the Automated Self-Administered 24 hr Dietary Recall Questionnaire three times in pregnancy (n = 48) to examine women's dietary fat intake in relation to infant temperament assessed using the Infant Behavior Questionnaire at 4-months old. The amount of saturated fat that the mother consumed was considered as a moderator of the association between total fat intake and child temperament. Results from a series of multiple linear regressions indicate that greater total fat intake was associated with poorer infant regulation and lower surgency. However, this second effect was moderated by maternal saturated fat intake, such that total fat intake was only related to infant surgency when mothers consumed above the daily recommended allowance of saturated fat. Under conditions of high total fat and high saturated fat, infants were rated as lower on surgency; under conditions of low total fat yet high saturated fat, infants were rated as higher on surgency. There were no associations between maternal prenatal fat intake and infant negative reactivity. These findings provide preliminary evidence that pregnant women's dietary fat intake is associated with infants' behavioral development, though future research is needed to address this report's limitations: a relatively small sample size, the use of self-report measures, and a lack of consideration of maternal and infant postnatal diet.
对啮齿动物和非人类灵长类动物的研究表明，母体孕期饮食中的脂肪摄入量与后代的行为功能有关，而这些行为功能表明其有精神病理学风险。这些研究结果在多大程度上适用于人类尚不清楚。本研究在孕期对48名女性进行了三次24小时饮食自动回忆调查问卷，以考察女性的饮食脂肪摄入量与婴儿气质之间的关系，婴儿气质在其4个月大时使用婴儿行为问卷进行评估。母亲摄入的饱和脂肪量被视为总脂肪摄入量与儿童气质之间关联的调节因素。一系列多元线性回归的结果表明，总脂肪摄入量越高，婴儿的自我调节能力越差，活跃度越低。然而，这第二种影响受到母体饱和脂肪摄入量的调节，即只有当母亲摄入的饱和脂肪量高于每日推荐摄入量时，总脂肪摄入量才与婴儿的活跃度有关。在总脂肪量高且饱和脂肪量高的情况下，婴儿的活跃度得分较低；在总脂肪量低但饱和脂肪量高的情况下，婴儿的活跃度得分较高。母体孕期脂肪摄入量与婴儿的消极反应性之间没有关联。这些发现提供了初步证据，表明孕妇的饮食脂肪摄入量与婴儿的行为发育有关，不过未来的研究需要解决本报告的局限性：样本量相对较小、使用自我报告测量方法以及未考虑母婴产后饮食。
