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小鼠触须毛囊分离、冷冻保存及移植到裸鼠后毛发轴的广泛生长

Extensive Hair Shaft Growth after Mouse Whisker Follicle Isolation, Cryopreservation and Transplantation in Nude Mice.

作者信息

Cao Wenluo, Li Lingna, Tran Benjamin, Kajiura Satoshi, Amoh Yasuyuki, Liu Fang, Hoffman Robert M

机构信息

AntiCancer Inc., San Diego, CA, 92111, United States of America.

Department of Surgery, University of California San Diego, San Diego, CA, 92103, United States of America.

出版信息

PLoS One. 2015 Dec 30;10(12):e0145997. doi: 10.1371/journal.pone.0145997. eCollection 2015.

DOI:10.1371/journal.pone.0145997
PMID:26716690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4696652/
Abstract

We previously demonstrated that whole hair follicles could be cryopreserved to maintain their stem-cells differentation potential. In the present study, we demonstrated that cryopreserved mouse whisker hair follicles maintain their hair growth potential. DMSO better cryopreserved mouse whisker follicles compared to glycerol. Cryopreserved hair follicles also maintained the hair follicle-associated-pluripotent (HAP) stem cells, evidenced by P75NTR expression. Subcutaneous transplantation of DMSO-cryopreserved hair follicles in nude mice resulted in extensive hair fiber growth over 8 weeks, indicating the functional recovery of hair shaft growth of cryopreserved hair follicles.

摘要

我们之前证明，整个毛囊可以被冷冻保存以维持其干细胞分化潜能。在本研究中，我们证明冷冻保存的小鼠触须毛囊保持其毛发生长潜能。与甘油相比，二甲基亚砜（DMSO）能更好地冷冻保存小鼠触须毛囊。冷冻保存的毛囊还维持了毛囊相关多能（HAP）干细胞，这通过P75NTR表达得以证明。在裸鼠中皮下移植经DMSO冷冻保存的毛囊，在8周内导致大量毛纤维生长，表明冷冻保存毛囊的毛干生长功能得以恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/f2f566ac9142/pone.0145997.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/7af2fc189f55/pone.0145997.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/589964966326/pone.0145997.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/5773bdcb8821/pone.0145997.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/5e87609c0bd1/pone.0145997.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/f2f566ac9142/pone.0145997.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/7af2fc189f55/pone.0145997.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/589964966326/pone.0145997.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/5773bdcb8821/pone.0145997.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/5e87609c0bd1/pone.0145997.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bee8/4696652/f2f566ac9142/pone.0145997.g005.jpg

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Cell Cycle. 2016 Oct;15(19):2619-2625. doi: 10.1080/15384101.2016.1208870. Epub 2016 Jul 18.

本文引用的文献

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Cell Cycle. 2015;14(14):2362-6. doi: 10.1080/15384101.2015.1042633. Epub 2015 May 13.
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Nestin-expressing hair follicle-accessible pluripotent stem cells for nerve and spinal cord repair.用于神经和脊髓修复的表达巢蛋白的毛囊可及多能干细胞
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Dev Cell. 2014 Dec 8;31(5):543-58. doi: 10.1016/j.devcel.2014.10.022. Epub 2014 Nov 26.
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