Agrawal Vishal, Sinha Mukty
Department of Medical Devices, National Institute of Pharmaceutical Education and Research-Ahmedabad, Ahmedabad-, 380054, India.
J Biomed Mater Res B Appl Biomater. 2017 May;105(4):904-925. doi: 10.1002/jbm.b.33599. Epub 2016 Jan 5.
Bone morphogenetic protein-2 (BMP-2) has unique bone regeneration property. The powerful osteoinductive nature makes it considered as second line of therapy in nonunion bone defect. A large number of carriers and delivery systems made up of different materials have been investigated for controlled and sustained release of BMP-2. The delivery systems are in the form of hydrogel, microsphere, nanoparticles, and fibers. The carriers used for the delivery are made up of metals, ceramics, polymers, and composites. Implantation of these protein-loaded carrier leads to cell adhesion, degradation which eventually releases the drug/protein at site specific. But, problems like ectopic growth, lesser protein delivery, inactivation of the protein are reported in the available carrier systems. Therefore, it is need of an hour to modify the available carrier systems as well as explore other biomaterials with desired properties. In this review, all the reported carrier systems made of metals, ceramics, polymers, composites are evaluated in terms of their processing conditions, loading capacity and release pattern of BMP-2. Along with these biomaterials, the attempts of protein modification by adding some functional group to BMP-2 or extracting functional peptides from the protein to achieve the desired effect, is also evaluated. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 904-925, 2017.
骨形态发生蛋白-2（BMP-2）具有独特的骨再生特性。其强大的骨诱导性质使其被视为骨不连缺损治疗的二线方案。为了实现BMP-2的可控和持续释放，人们研究了大量由不同材料组成的载体和递送系统。这些递送系统呈水凝胶、微球、纳米颗粒和纤维的形式。用于递送的载体由金属、陶瓷、聚合物和复合材料制成。植入这些负载蛋白质的载体可导致细胞黏附、降解，最终在特定部位释放药物/蛋白质。但是，现有载体系统中存在诸如异位生长、蛋白质递送量较低、蛋白质失活等问题。因此，迫切需要改进现有的载体系统，并探索具有所需特性的其他生物材料。在本综述中，对所有已报道的由金属、陶瓷、聚合物、复合材料制成的载体系统在其加工条件、BMP-2的负载能力和释放模式方面进行了评估。除了这些生物材料，还评估了通过给BMP-2添加一些官能团或从该蛋白质中提取功能性肽来实现预期效果的蛋白质修饰尝试。© 2016威利期刊公司。《生物医学材料研究杂志》B部分：应用生物材料，105B：904 - 925，2017年。
