牙干细胞在再生中的作用。
The role of dental stem cells in regeneration.
作者信息
Maxim Monica Angela, Soritau Olga, Baciut Mihaela, Bran Simion, Baciut Grigore
机构信息
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Prof. Dr. Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania.
出版信息
Clujul Med. 2015;88(4):479-82. doi: 10.15386/cjmed-475. Epub 2015 Nov 15.
Abstract
Mesenchymal stem cells (MSCs) are adult stem cells that have the capacity of rising multiple cell types. A rich source of mesenchymal stem cells is represented by the dental tissues: the periodontal ligament, the dental pulp, the apical papilla, the dental follicle and the deciduous teeth. The aim of this review is to characterize the main dental- derived mesenchymal stem cell population, and to show their important role in tissue regeneration based on their properties : the multi-potency, the high proliferation rate, the differentiation in multiple cell lineages, the high cell viability and the positive expression for mesenchymal cell markers. Tissue regeneration or de novo' formation of craniofacial structures is the future of regenerative medicine, offering a solution for congenital malformations, traumas and other diseases.
摘要
间充质干细胞（MSCs）是具有分化为多种细胞类型能力的成体干细胞。牙组织是间充质干细胞的丰富来源：牙周韧带、牙髓、根尖乳头、牙囊和乳牙。本综述的目的是描述主要的牙源性间充质干细胞群体，并基于其特性展示它们在组织再生中的重要作用：多能性、高增殖率、向多种细胞谱系分化、高细胞活力以及间充质细胞标志物的阳性表达。颅面结构的组织再生或从头形成是再生医学的未来，为先天性畸形、创伤和其他疾病提供了解决方案。
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