ToxStrategies, Inc., Austin, Texas 78759; email:
US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760; email:
Annu Rev Food Sci Technol. 2016;7:117-37. doi: 10.1146/annurev-food-041715-033243. Epub 2016 Jan 6.
The debate on the safety of and regulatory approaches for caffeine continues among various stakeholders and regulatory authorities. This decision-making process comes with significant challenges, particularly when considering the complexities of the available scientific data, making the formulation of clear science-based regulatory guidance more difficult. To allow for discussions of a number of key issues, the North American Branch of the International Life Sciences Institute (ILSI) convened a panel of subject matter experts for a caffeine-focused session entitled "Caffeine: Friend or Foe?," which was held during the 2015 ILSI Annual Meeting. The panelists' expertise covered topics ranging from the natural occurrence of caffeine in plants and interindividual metabolism of caffeine in humans to specific behavioral, reproductive, and cardiovascular effects related to caffeine consumption. Each presentation highlighted the potential risks, benefits, and challenges that inform whether caffeine exposure warrants concern. This paper aims to summarize the key topics discussed during the session.
关于咖啡因的安全性和监管方法，不同利益相关者和监管机构仍在争论不休。这一决策过程面临着重大挑战，尤其是在考虑到现有科学数据的复杂性时，使得制定明确基于科学的监管指导更加困难。为了能够讨论一些关键问题，国际生命科学学会（ILSI）北美分会召集了一组主题专家，就咖啡因相关的问题召开了一次名为“咖啡因：朋友还是敌人？”的会议，该会议是在 2015 年 ILSI 年会上举行的。小组成员的专业知识涵盖了从咖啡因在植物中的自然存在和人类中咖啡因的个体间代谢，到与咖啡因摄入相关的具体行为、生殖和心血管效应等多个主题。每个演讲都强调了潜在的风险、益处和挑战，这些都影响着咖啡因暴露是否值得关注。本文旨在总结会议期间讨论的主要议题。
