Toma Kenichi, Wang Tien-Cheng, Hanashima Carina
Laboratory for Neocortical Development, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan.
Department of Biology, Graduate School of Science, Kobe University, Kobe, 657-8501, Japan.
Dev Growth Differ. 2016 Jan;58(1):59-72. doi: 10.1111/dgd.12257. Epub 2016 Jan 9.
The development of a multicellular organism involves time-dependent changes in molecular and cellular states; therefore 'time' is an indispensable mathematical parameter of ontogenesis. Regardless of their inextricable relationship, there is a limited number of events for which the output of developmental phenomena primarily uses temporal cues that are generated through multilevel interactions between molecules, cells, and tissues. In this review, we focus on neural stem cells, which serve as a faithful decoder of temporal cues to transmit biological information and generate specific output in the developing nervous system. We further explore the identity of the temporal information that is encoded in neural development, and how this information is decoded into various cellular fate decisions.
多细胞生物体的发育涉及分子和细胞状态随时间的变化；因此，“时间”是个体发育不可或缺的数学参数。尽管它们之间存在着千丝万缕的关系，但发育现象的输出主要利用通过分子、细胞和组织之间的多级相互作用产生的时间线索的事件数量有限。在这篇综述中，我们聚焦于神经干细胞，它们作为时间线索的忠实解码器，在发育中的神经系统中传递生物信息并产生特定输出。我们进一步探讨了神经发育中编码的时间信息的特征，以及这些信息如何被解码为各种细胞命运决定。
