Koh Victor, Cheung Carol Y, Li Xiang, Tian Dechao, Wang Jie Jin, Mitchell Paul, Cheng Ching-Yu, Wong Tien Y
a Singapore Eye Research Institute, Singapore National Eye Centre.
b Department of Ophthalmology , Yong Loo Lin School of Medicine, National University of Singapore.
Ophthalmic Epidemiol. 2016;23(1):6-13. doi: 10.3109/09286586.2015.1082604. Epub 2016 Jan 11.
To describe the prevalence of retinal vein occlusion (RVO) and its risk factors in a multi-ethnic Asian population.
This population-based study of 10,033 participants (75.7% response rate) included Chinese, Indian and Malay persons aged 40 years and older. A comprehensive ophthalmic examination, standardized interviews and laboratory blood tests were performed. Digital fundus photographs were assessed for presence of RVO following the definitions used in the Blue Mountains Eye Study. Regression analysis models were constructed to study the relationship between ocular and systemic factors and RVO. Age-specific prevalence rates of RVO were applied to project the number of people affected in Asia from 2013 to 2040.
The overall crude prevalence of RVO was 0.72% (n = 71; 95% confidence interval, CI, 0.54-0.87%). The crude prevalence of RVO was similar in Chinese, Indian and Malay participants (p = 0.865). In multivariable regression models, significant risk factors of RVO included increased age (odds ratio, OR, 1.03, 95% CI 1.01-1.06), hypertension (OR 3.65, 95% CI 1.61-8.31), increased serum creatinine (OR 1.04, 95% CI 1.01-1.06, per 10 mmol/L increase), history of heart attack (OR 2.25, 95% CI 1.11-4.54) and increased total cholesterol (OR 1.31, 95% CI 1.07-1.59, per 1 mmol/L increase). None of the ocular parameters were associated with RVO. RVO is estimated to affect up to 16 and 21 million people in Asia by 2020 and 2040, respectively.
RVO was detected in 0.72% of a multi-ethnic Asian population aged 40-80 years in Singapore. The significant systemic risk factors of RVO are consistent with studies in white populations.
描述视网膜静脉阻塞（RVO）在多民族亚洲人群中的患病率及其危险因素。
这项基于人群的研究纳入了10033名参与者（应答率为75.7%），包括40岁及以上的华裔、印度裔和马来裔人群。进行了全面的眼科检查、标准化访谈和实验室血液检测。根据蓝山眼研究中使用的定义，对数码眼底照片进行评估以确定是否存在RVO。构建回归分析模型以研究眼部和全身因素与RVO之间的关系。应用RVO的年龄特异性患病率来预测2013年至2040年亚洲受影响的人数。
RVO的总体粗患病率为0.72%（n = 71；95%置信区间，CI，0.54 - 0.87%）。华裔、印度裔和马来裔参与者中RVO的粗患病率相似（p = 0.865）。在多变量回归模型中，RVO的显著危险因素包括年龄增加（比值比，OR，1.03，95%CI 1.01 - 1.06）、高血压（OR 3.65，95%CI 1.61 - 8.31）、血清肌酐升高（OR 1.04，95%CI 1.01 - 1.06，每增加10 mmol/L）、心脏病发作史（OR 2.25，95%CI 1.11 - 4.54）和总胆固醇升高（OR 1.31，95%CI 1.
