• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

培养的气道上皮细胞合成内皮素。

Formation of endothelin by cultured airway epithelial cells.

作者信息

Black P N, Ghatei M A, Takahashi K, Bretherton-Watt D, Krausz T, Dollery C T, Bloom S R

机构信息

Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, England.

出版信息

FEBS Lett. 1989 Sep 11;255(1):129-32. doi: 10.1016/0014-5793(89)81075-0.

DOI:10.1016/0014-5793(89)81075-0
PMID:2676594
Abstract

Immunoreactivity to endothelin was detected in conditioned culture medium from both canine and porcine tracheal epithelial cells. Gel permeation chromatography and fast protein liquid chromatography were used to confirm the identity of the endothelin. The two peaks demonstrated on fast protein liquid chromatography co-eluted with endothelin 1 and endothelin 3 respectively.

摘要

在犬和猪气管上皮细胞的条件培养基中检测到了对内皮素的免疫反应性。采用凝胶渗透色谱法和快速蛋白质液相色谱法来确认内皮素的特性。快速蛋白质液相色谱法上显示的两个峰分别与内皮素1和内皮素3共洗脱。

相似文献

1
Formation of endothelin by cultured airway epithelial cells.培养的气道上皮细胞合成内皮素。
FEBS Lett. 1989 Sep 11;255(1):129-32. doi: 10.1016/0014-5793(89)81075-0.
2
Production of endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes.培养的牛视网膜内皮细胞产生内皮素-1以及相关周细胞上存在内皮素受体。
Diabetes. 1989 Sep;38(9):1200-2. doi: 10.2337/diab.38.9.1200.
3
Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1.猪主动脉内皮细胞培养上清液中内皮素相关肽的分析：内皮素-1生物合成途径的证据
Biochem Biophys Res Commun. 1989 Aug 15;162(3):1287-94. doi: 10.1016/0006-291x(89)90813-9.
4
Presence of immunoreactive endothelin in human milk.人乳中免疫反应性内皮素的存在。
FEBS Lett. 1990 Feb 12;261(1):184-6. doi: 10.1016/0014-5793(90)80666-7.
5
Endothelin-1 stimulates proliferation of normal airway epithelial cells.
Biochem Biophys Res Commun. 1995 Jul 26;212(3):953-9. doi: 10.1006/bbrc.1995.2062.
6
Production of endothelin-1 by rat cultured mesangial cells.大鼠培养系膜细胞产生内皮素-1。
Biochem Biophys Res Commun. 1990 Jun 15;169(2):462-8. doi: 10.1016/0006-291x(90)90354-p.
7
Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.内皮素-3是一种新型神经肽：猪脑中内皮素-1和内皮素-3的分离与序列测定。
Biochem Biophys Res Commun. 1989 Oct 16;164(1):587-93. doi: 10.1016/0006-291x(89)91760-9.
8
Detection and identification of endothelin-1 immunoreactivity in rat and porcine thyroid follicular cells.大鼠和猪甲状腺滤泡细胞中内皮素-1免疫反应性的检测与鉴定。
Endocrinology. 1992 Jan;130(1):544-6. doi: 10.1210/endo.130.1.1727722.
9
Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme.磷酰胺素是一种金属蛋白酶抑制剂，它通过抑制一种大内皮素-1转化酶来抑制培养的内皮细胞分泌内皮素-1。
Biochem Biophys Res Commun. 1990 Sep 14;171(2):669-75. doi: 10.1016/0006-291x(90)91198-2.
10
Chromatographic characterization of immunoreactive endothelin in rat lung.大鼠肺中免疫反应性内皮素的色谱表征
Life Sci. 1990;46(6):405-9. doi: 10.1016/0024-3205(90)90083-4.

引用本文的文献

1
Endothelin-1 in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction.运动诱发性支气管收缩的过敏性哮喘患者呼出气冷凝物中的内皮素-1
Respir Res. 2007 Oct 31;8(1):76. doi: 10.1186/1465-9921-8-76.
2
Inhibition of basal and stimulated release of endothelin-1 from guinea pig tracheal epithelial cells in culture by beta 2-adrenoceptor agonists and cyclic AMP enhancers.β2-肾上腺素能受体激动剂和环磷酸腺苷增强剂对培养的豚鼠气管上皮细胞中内皮素-1基础释放和刺激释放的抑制作用。
Inflammation. 2007 Oct;30(5):136-47. doi: 10.1007/s10753-007-9030-6.
3
Neurology of allergic inflammation and rhinitis.
变应性炎症与鼻炎的神经学
Curr Allergy Asthma Rep. 2002 May;2(3):210-5. doi: 10.1007/s11882-002-0021-2.
4
Role of endothelin-1 in lung disease.内皮素-1在肺部疾病中的作用。
Respir Res. 2001;2(2):90-101. doi: 10.1186/rr44. Epub 2001 Feb 22.
5
Different endothelins stimulate cytokine production by peritoneal macrophages and microglial cell line.不同的内皮素可刺激腹膜巨噬细胞和小胶质细胞系产生细胞因子。
Immunology. 1998 Jan;93(1):109-14. doi: 10.1046/j.1365-2567.1998.00391.x.
6
Influence of respiratory tract viral infection on endothelin-1-induced potentiation of cholinergic nerve-mediated contraction in mouse trachea.呼吸道病毒感染对内皮素-1诱导的小鼠气管胆碱能神经介导收缩增强作用的影响。
Br J Pharmacol. 1996 Nov;119(5):891-8. doi: 10.1111/j.1476-5381.1996.tb15756.x.
7
Time course of changes in ETB receptor density and function in tracheal airway smooth muscle during respiratory tract viral infection in mice.小鼠呼吸道病毒感染期间气管气道平滑肌中ETB受体密度和功能变化的时间进程。
Br J Pharmacol. 1996 Mar;117(6):1222-8. doi: 10.1111/j.1476-5381.1996.tb16719.x.
8
Endothelins-induce cyclicAMP formation in the guinea-pig trachea through an ETA receptor- and cyclooxygenase-dependent mechanism.内皮素通过ETA受体和环氧化酶依赖性机制诱导豚鼠气管中的环磷酸腺苷形成。
Br J Pharmacol. 1996 Jun;118(3):531-6. doi: 10.1111/j.1476-5381.1996.tb15434.x.
9
Occurrence, distribution and possible role of the regulatory peptide endothelin in the nasal mucosa.调节肽内皮素在鼻黏膜中的发生、分布及可能作用
Cell Tissue Res. 1993 Nov;274(2):241-7. doi: 10.1007/BF00318743.
10
Induction by endothelin-1 of epithelium-dependent relaxation of guinea-pig trachea in vitro: role for nitric oxide.内皮素-1对豚鼠气管上皮依赖性舒张的体外诱导作用：一氧化氮的作用
Br J Pharmacol. 1993 Jul;109(3):637-44. doi: 10.1111/j.1476-5381.1993.tb13620.x.