全氟碳化合物可减轻百草枯诱导的急性肺损伤大鼠的炎症细胞因子、氧化应激和组织病理学变化。
Perfluorocarbon attenuates inflammatory cytokines, oxidative stress and histopathologic changes in paraquat-induced acute lung injury in rats.
机构信息
Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Student Researches Committee, Ilam University of Medical Sciences, Ilam, Iran.
出版信息
Environ Toxicol Pharmacol. 2016 Mar;42:9-15. doi: 10.1016/j.etap.2015.12.002. Epub 2015 Dec 17.
The effects of perfluorocarbon (PFC) on paraquat (PQ) induced acute lung injury (ALI) was evaluated among rats. Twenty four Wistar rats were divided into 4 groups: control group injected by saline physiologic 0.9%, PFC group injected by Perfluorocarbon, PQ group injected by PQ and PQ+PFC group injected by PFC one hour after receiving paraquat. Bronchoalveular fluid content, inflammatory cytokines, oxidative and histopathologic changes were measured after 72 h. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1(TGF-β1) in the PQ group were increased compared to either control or PFC groups, but their levels decreased in PQ+PFC group significantly (p<0.05). Also, histopathologic evaluation revealed an increase in malondialdehyde (MDA) and hydroxyproline (HP) in the PQ group but a decrease in PQ+PFC group significantly (p<0.01). PFC emulsion by its anti-inflammatory, anti-oxidative and anti-fibrotic properties can reduce the inflammatory and fibrotic alterations, pulmonary oedema, and pulmonary histopathologic changes created by PQ.
研究了全氟碳化合物（PFC）对百草枯（PQ）诱导的急性肺损伤（ALI）的影响。将 24 只 Wistar 大鼠分为 4 组：生理盐水生理 0.9%对照组、PFC 组、PQ 组和 PQ+PFC 组。在接受百草枯后 1 小时，测量支气管肺泡灌洗液含量、炎症细胞因子、氧化和组织病理学变化。与对照组或 PFC 组相比，PQ 组的白细胞介素 6（IL-6）、肿瘤坏死因子-α（TNF-α）和转化生长因子-β1（TGF-β1）水平升高，但 PQ+PFC 组显著降低（p<0.05）。此外，组织病理学评估显示 PQ 组丙二醛（MDA）和羟脯氨酸（HP）增加，但 PQ+PFC 组显著降低（p<0.01）。PFC 乳剂通过其抗炎、抗氧化和抗纤维化特性，可减轻 PQ 引起的炎症和纤维化改变、肺水肿和肺组织病理学变化。
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