Ostovar Tahmine, Rezaei Sahar, Shokri-Afra Hajar, Samavarchi Tehrani Sadra, Namvarjah Fatemeh, Aliabadi Masoume, Effatpanah Hosein, Moradi-Sardareh Hemen
International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Int J Mol Cell Med. 2023;12(4):423-434. doi: 10.22088/IJMCM.BUMS.12.4.423.
Pulmonary fibrosis (PF) is a lethal inflammatory disease and there has been no effective medication for this progressive disease up to now. Paraquat is commonly used in agricultural settings to control weed growth and is one of the important risk factors for PF. Additionally, emerging evidence has demonstrated () fruit extract has anti-fibrotic, anti-inflammatory, and antioxidant properties. We aimed to evaluate whether fruit hydroalcoholic extract has a positive effect against Paraquat-induced PF in rats. 30 male Wistar rats were randomly divided into 5 groups, which included: a control group, a Paraquat control group, a group with a dose of 20 mg/kg, a group with a dose of 30 mg/kg, a group with a dose of 50 mg/kg. After 21 days of the treatment, levels of hydroxyproline and malondialdehyde (MDA) in lung tissue were assessed and lung indices and semi-quantitative histopathological changes were determined. The results showed that treatment with , led to increased weight gain, whereas reduced lung weight. demonstrated a decreasing effect on levels of MDA, and hydroxyproline in lung tissue. Moreover, histopathological data and the number of lung indices indicated the preventive role of Paraquat-induced PF in rats.
肺纤维化（PF）是一种致命的炎症性疾病，迄今为止，对于这种进行性疾病尚无有效的药物治疗。百草枯常用于农业生产中控制杂草生长，是导致PF的重要危险因素之一。此外，新出现的证据表明（）水果提取物具有抗纤维化、抗炎和抗氧化特性。我们旨在评估（）水果水醇提取物对百草枯诱导的大鼠PF是否具有积极作用。将30只雄性Wistar大鼠随机分为5组，包括：对照组、百草枯对照组、剂量为20mg/kg的（）组、剂量为30mg/kg的（）组、剂量为50mg/kg的（）组。治疗21天后，评估肺组织中羟脯氨酸和丙二醛（MDA）水平，并测定肺指数和半定量组织病理学变化。结果表明，用（）治疗导致体重增加，而肺重量减轻。（）对肺组织中MDA和羟脯氨酸水平有降低作用。此外，组织病理学数据和肺指数数量表明（）对大鼠百草枯诱导的PF具有预防作用。
