Taylor Lem, Mumford Petey, Roberts Mike, Hayward Sara, Mullins Jacy, Urbina Stacie, Wilborn Colin
Department of Exercise and Sport Science, Human Performance Lab & Exercise Biochemistry Lab, University of Mary Hardin-Baylor, Belton, TX USA.
School of Kinesiology, Auburn University, Auburn, AL USA.
J Int Soc Sports Nutr. 2016 Jan 13;13:2. doi: 10.1186/s12970-016-0113-3. eCollection 2016.
Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in certain coffee (Coffea) species, fruits (Cupuacu [Theobroma grandiflorum]), and tea (Camellia assamica, var. kucha) that has anti-inflammatory, analgesic, and neuro-locomotor properties. Recent preliminary research has also reported increased feelings of energy, reduced fatigue, and strong effects on improving focus, concentration, and motivation to exercise. The purpose of this study was to examine the safety and non-habituating effects of TeaCrine®, a nature-identical, chemically equivalent bioactive version of theacrine.
Sixty healthy men (mean ± SD age, height, weight: 22.9 ± 4.7 years, 183.5 ± 9.2 cm, 86.5 ± 13.7 kg) and women (22.3 ± 4.5 years, 165.2 ± 12.3 cm, 69.0 ± 17.4 kg) were placed into one of three groups: placebo (PLA, n = 20), 200 mg TeaCrine® (LD, n = 19) or 300 mg Teacrine® (HD, n = 21) and ingested their respective supplement once daily for 8 weeks. Primary outcomes were fasting clinical safety markers (heart rate, blood pressure, lipid profiles, hematologic blood counts, biomarkers of liver/kidney/immune function) and energy, focus, concentration, anxiety, motivation to exercise, and POMS measured prior to daily dosing to ascertain potential tachyphylactic responses and habituation effects. Data were analyzed via two-way (group × time) ANOVAs and statistical significance was accepted at p < 0.05.
All values for clinical safety markers fell within normal limits and no group × time interactions were noted. No evidence of habituation was noted as baseline values for energy, focus, concentration, anxiety, motivation to exercise, and POMS remained stable in all groups across the 8-week study protocol.
These findings support the clinical safety and non-habituating neuro-energetic effects of TeaCrine® supplementation over 8 weeks of daily use (up to 300 mg/day). Moreover, there was no evidence of a tachyphylactic response that is typical of neuroactive agents such as caffeine and other stimulants.
茶氨酸（1,3,7,9 - 四甲基尿酸）是一种嘌呤生物碱，存在于某些咖啡（咖啡属）品种、水果（可可树[大花可可树]）和茶叶（阿萨姆茶树，变种库恰）中，具有抗炎、镇痛和神经运动特性。最近的初步研究还报告称，它能增强精力感、减轻疲劳，并对提高注意力、专注力和运动积极性有显著效果。本研究的目的是检验茶氨酸的天然等同物、化学等效生物活性版本茶氨酸（TeaCrine®）的安全性和非成瘾性作用。
60名健康男性（平均年龄±标准差，年龄、身高、体重：22.9±4.7岁，183.5±9.2厘米，86.5±13.7千克）和女性（22.3±4.5岁，165.2±12.3厘米，69.0±17.4千克）被分为三组之一：安慰剂组（PLA，n = 20）、200毫克茶氨酸（TeaCrine®）组（LD，n = 19）或300毫克茶氨酸（TeaCrine®）组（HD，n = 21），并每天服用各自的补充剂，持续8周。主要结果是空腹临床安全指标（心率、血压、血脂谱、血液学血细胞计数、肝/肾/免疫功能生物标志物）以及每日给药前测量的精力、注意力、专注力、焦虑、运动积极性和POMS，以确定潜在的快速耐受反应和成瘾效应。数据通过双向（组×时间）方差分析进行分析，p < 0.05时接受统计学显著性。
临床安全指标的所有值均在正常范围内，未观察到组×时间交互作用。在为期8周的研究方案中，所有组的精力、注意力、专注力、焦虑、运动积极性和POMS的基线值保持稳定，未发现成瘾迹象。
这些发现支持了每日使用（高达300毫克/天）8周的茶氨酸（TeaCrine®）补充剂的临床安全性和非成瘾性神经能量作用。此外，没有证据表明存在咖啡因和其他兴奋剂等神经活性剂典型的快速耐受反应。
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