De Souza M J, Maresh C M, Maguire M S, Kraemer W J, Flora-Ginter G, Goetz K L
Department of Sport, Leisure, and Exercise Science, University of Connecticut, Storrs 06268.
J Appl Physiol (1985). 1989 Aug;67(2):736-43. doi: 10.1152/jappl.1989.67.2.736.
The effects of menstrual cycle phase (early follicular vs. midluteal) and menstrual status (eumenorrhea vs. amenorrhea) on plasma arginine vasopressin (AVP), renin activity (PRA), and aldosterone (ALDO) were studied before and after 40 min of submaximal running (80% maximal O2 uptake). Eumenorrheic runners were studied in the early follicular and midluteal phases determined by urinary luteinizing hormone and progesterone and plasma estradiol and progesterone assays; amenorrheic runners were studied once. Menstrual phase was associated with no significant differences in preexercise plasma AVP or PRA, but ALDO levels were significantly higher during the midluteal phase than the early follicular phase. Plasma AVP and PRA were significantly elevated at 4 min after the 40-min run in the eumenorrheic runners during both menstrual phases and returned to preexercise levels by 40 min after exercise. Plasma ALDO responses at 4 and 40 min after exercise were higher in the midluteal phase than the early follicular phase. Menstrual status was associated with no significant differences in preexercise AVP or PRA; however, ALDO levels were significantly higher in the amenorrheic runners. After exercise, responses in the amenorrheic runners were comparable with the eumenorrheic runners during the early follicular phase. Thus, submaximal exercise elicits significant increases in plasma AVP and PRA independent of menstrual phase and status. However, plasma ALDO is significantly elevated during the midluteal phase, exercise results in a greater response during this menstrual phase, and amenorrheic runners have elevated resting levels of ALDO.
研究了月经周期阶段（卵泡早期与黄体中期）和月经状态（正常月经与闭经）对次最大强度跑步（最大摄氧量的80%）40分钟前后血浆精氨酸加压素（AVP）、肾素活性（PRA）和醛固酮（ALDO）的影响。通过尿促黄体生成素、孕酮以及血浆雌二醇和孕酮检测确定处于卵泡早期和黄体中期的正常月经跑步者；闭经跑步者仅进行一次研究。月经周期阶段与运动前血浆AVP或PRA无显著差异，但黄体中期的ALDO水平显著高于卵泡早期。在两个月经周期阶段，正常月经跑步者在40分钟跑步后的4分钟时，血浆AVP和PRA显著升高，并在运动后40分钟恢复到运动前水平。运动后4分钟和40分钟时，黄体中期的血浆ALDO反应高于卵泡早期。月经状态与运动前AVP或PRA无显著差异；然而，闭经跑步者的ALDO水平显著更高。运动后，闭经跑步者的反应与卵泡早期的正常月经跑步者相当。因此，次最大强度运动可使血浆AVP和PRA显著升高，且与月经周期阶段和状态无关。然而，黄体中期血浆ALDO显著升高，在此月经周期阶段运动导致的反应更大，且闭经跑步者的静息ALDO水平升高。
