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白细胞介素4诱导正常人B淋巴细胞选择性产生白细胞介素6。

Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes.

作者信息

Smeland E B, Blomhoff H K, Funderud S, Shalaby M R, Espevik T

机构信息

Department of Pathology, Institute for Cancer Research, Montebello, Oslo, Norway.

出版信息

J Exp Med. 1989 Oct 1;170(4):1463-8. doi: 10.1084/jem.170.4.1463.

DOI:10.1084/jem.170.4.1463
PMID:2677211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189485/
Abstract

In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production.

摘要

在本文中，我们已表明，经过广泛纯化的人B淋巴细胞在接受白细胞介素-4（IL-4）处理后会显著产生白细胞介素-6（IL-6）。加入抗μ链抗体可增强IL-4对IL-6产生的作用。当给予静止B细胞时，所测试的其他细胞因子，如肿瘤坏死因子-α（TNF-α）和-β（TNF-β）、干扰素-γ（IFN-γ）、白细胞介素-1（IL-1）、白细胞介素-2（IL-2）和白细胞介素-5（IL-5）均未诱导IL-6分泌。尽管B细胞在受到刺激时通常也会产生TNF-α和TNF-β，但IL-4并未诱导TNF分泌，且似乎对IL-6的产生具有特定作用。

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本文引用的文献

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