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肿瘤发生的关键点：通过单细胞蛋白质组学分析致癌物引发的相变

Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.

作者信息

Poovathingal Suresh Kumar, Kravchenko-Balasha Nataly, Shin Young Shik, Levine Raphael David, Heath James R

机构信息

Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 127-72, 1200 E. California Blvd, Pasadena, CA, 91125, USA.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, L-4362, Luxembourg.

出版信息

Small. 2016 Mar;12(11):1425-31. doi: 10.1002/smll.201501178. Epub 2016 Jan 18.

DOI:10.1002/smll.201501178
PMID:26780498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4886749/
Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

摘要

通过将单细胞数据视为在不同稳态之间转变的开放系统的波动，对化学诱导致癌作用进行了动力学单细胞蛋白质组学研究。类似于一级相变，观察到了相共存和自由度的丧失。在致癌转化的传统生物标志物出现之前很久就检测到了这种转变。

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本文引用的文献

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2
Stem cell differentiation as a many-body problem.干细胞分化作为一个多体问题。
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Microfluidics-based single-cell functional proteomics for fundamental and applied biomedical applications.基于微流控技术的单细胞功能蛋白质组学在基础和应用生物医学中的应用
Annu Rev Anal Chem (Palo Alto Calif). 2014;7:275-95. doi: 10.1146/annurev-anchem-071213-020323. Epub 2014 Jun 2.
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Glioblastoma cellular architectures are predicted through the characterization of two-cell interactions.通过对两细胞相互作用的特征分析来预测胶质母细胞瘤的细胞结构。
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Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.Cox-2 在人乳腺癌细胞中的表达作为上皮间质转化和侵袭性的关键决定因素。
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Hypoxia induces a phase transition within a kinase signaling network in cancer cells.缺氧诱导癌细胞中激酶信号网络的相变。
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