Department of Ophthalmology, Ewha Womans University, Seoul, Republic of Korea.
Eye (Lond). 2013 Mar;27(3):387-91. doi: 10.1038/eye.2012.273. Epub 2013 Jan 4.
To assess the change in subfoveal choroidal thickness (SFCT) in central serous chorioretinopathy (CSC) following spontaneous resolution and low-fluence photodynamic therapy (PDT) using the enhanced depth imaging optical coherence tomography (EDI-OCT).
A total of 36 consecutive eyes of 36 patients were included in this retrospective study: 16 eyes with spontaneously resolved CSC and 20 eyes with PDT-treated CSC. Best-corrected visual acuity and SFCT were evaluated at each visit until complete absorption of the subretinal fluid. SFCT of 32 normal subjects were also measured, as the control group. Wilcoxon's singed-rank test was used to evaluate the effects of spontaneous resolution and PDT. To compare the SFCT of the eyes with resolved CSC with that of the normal eyes, Mann-Whitney U-test with Bonferroni correction was also employed.
SFCT of patients was 459.16±77.50 μm at the baseline, and decreased to 419.31±54.49μm after a spontaneous resolution (P=0.015). However, SFCT was not normalized in comparison with that of the normal subjects (P<0.001). SFCT in PDT group was also reduced from 416.43±74.01 to 349.50±88.99 μm (P<0.001), with no significant difference with the normal value (P=0.087).
SFCT in patients with CSC decreased both after spontaneous resolution and low-fluence PDT. However, only in the PDT group, after disappearance of subretinal fluid, did it decrease to that of normal subjects.
使用增强深度成像光学相干断层扫描（EDI-OCT）评估中心性浆液性脉络膜视网膜病变（CSC）自发消退和低强度光动力疗法（PDT）后中心凹下脉络膜厚度（SFCT）的变化。
本回顾性研究共纳入 36 例 36 只眼：16 只眼为自发性 CSC 消退，20 只眼为 PDT 治疗的 CSC。每次就诊时均评估最佳矫正视力和 SFCT，直到视网膜下液完全吸收。还测量了 32 名正常受试者的 SFCT，作为对照组。Wilcoxon 符号秩检验用于评估自发消退和 PDT 的影响。为了比较消退的 CSC 眼与正常眼的 SFCT，还采用了校正后的 Mann-Whitney U 检验。
患者基线时的 SFCT 为 459.16±77.50 μm，自发消退后降至 419.31±54.49 μm（P=0.015）。然而，与正常对照组相比，SFCT 并未恢复正常（P<0.001）。PDT 组的 SFCT 也从 416.43±74.01 降至 349.50±88.99 μm（P<0.001），与正常值无显著差异（P=0.087）。
CSC 患者在自发消退和低强度 PDT 后 SFCT 均降低。然而，只有在 PDT 组，当视网膜下液消失后，SFCT 才降低至正常水平。
