Instituto de Ciencias Agrarias, Consejo Superior de Investigaciones Científicas , Serrano 115-bis, 28006 Madrid, Spain.
Departamento de Química Orgánica, Instituto de Biotecnología, Universidad de Granada , Campus de Fuente Nueva, s/n, 18071 Granada, Spain.
J Nat Prod. 2016 Feb 26;79(2):261-6. doi: 10.1021/acs.jnatprod.5b00501. Epub 2016 Jan 22.
Several preparations were obtained from the aerial parts of predomesticated Lavandula luisieri, including the essential oil and ethanolic, hexane, and ethyl acetate extractives. Additionally, pilot plant vapor pressure extraction was carried out at a pressure range of 0.5-1.0 bar to give a vapor pressure oil and an aqueous residue. A chemical study of the hexane extract led to the isolation of six necrodane derivatives (1, 2, and 4-7), with four of these (1, 2, 5, and 7) being new, as well as camphor, a cadinane sesquiterpene (9), tormentic acid, and ursolic acid. The EtOAc and EtOH extracts contained a mixture of phenolic compounds with rosmarinic acid being the major component. Workup of the aqueous residue resulted in the isolation of the necrodane 3 and (1R*,2S*,4R*)-p-menth-5-ene-1,2,8-triol (8), both new natural compounds. The structures of the new compounds were established based on their spectroscopic data. The phytotoxic and nematicidal activities of these compounds were evaluated.
从驯化的薰衣草（Lavandula luisieri）的地上部分中获得了几种制剂，包括精油和醇提物、正己烷提取物、乙酸乙酯提取物。此外，在 0.5-1.0 巴的压力范围内进行了中试规模的减压蒸馏提取，得到减压蒸馏油和水相残渣。对正己烷提取物的化学研究导致分离出六种 necrodane 衍生物（1、2 和 4-7），其中 4 种（1、2、5 和 7）为新化合物，还有樟脑、倍半萜（9）、没食子酸和熊果酸。乙酸乙酯和乙醇提取物含有酚类化合物的混合物，其中迷迭香酸是主要成分。水相残渣的处理导致分离出 necrodane 3 和（1R*,2S*,4R*）-p-menth-5-ene-1,2,8-triol（8），两者均为新的天然化合物。根据它们的光谱数据确定了新化合物的结构。评估了这些化合物的植物毒性和杀线虫活性。
