Arantes Sílvia, Candeias Fátima, Lopes Orlando, Lima Mónica, Pereira Marízia, Tinoco Teresa, Cruz-Morais J, Martins M Rosário
Departamento de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal.
ICAAM - Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Universidade de Évora, Évora, Portugal.
Planta Med. 2016 Sep;82(14):1266-73. doi: 10.1055/s-0042-104418. Epub 2016 Apr 28.
The present study was carried out to evaluate the chemical and pharmacological properties of the essential oil of Lavandula stoechas subsp. luisieri, which is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, such as 1,8-cineole, lavandulol, and necrodane derivatives, are the main components of essential oil. It revealed important antioxidant activity with a high ability to inhibit lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as gram-positive and gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67 % at 60 min with the dose of 200 mg/kg and the anti-inflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83 %) that is higher than dexamethasone 1 mg/Kg (69 %). Besides, animals exhibited normal behaviour after essential oil administration, revealing low toxicity. The essential oil of L. luisieri from Alentejo presents important pharmacological properties and low toxicity, and is a promised candidate to be used as a food supplement or in pharmaceutical applications.
本研究旨在评估葡萄牙阿连特茹地区广泛分布的野生灌木路易斯熏衣草（Lavandula stoechas subsp. luisieri）精油的化学和药理特性。含氧单萜类化合物，如1,8-桉叶素、薰衣草醇和降蒈烷衍生物，是该精油的主要成分。它具有重要的抗氧化活性，对脂质过氧化具有很强的抑制能力，并且对多种微生物，如革兰氏阳性菌、革兰氏阴性菌和致病性酵母菌，都有显著的抑制作用。在大鼠身上研究的镇痛作用呈剂量依赖性，在剂量为200mg/kg时，60分钟时镇痛效果达到最大值67%，该剂量的抗炎活性导致对角叉菜胶诱导的大鼠爪肿胀的抑制率为83%，高于1mg/kg地塞米松的抑制率（69%）。此外，给动物施用精油后其行为正常，表明毒性较低。来自阿连特茹地区的路易斯熏衣草精油具有重要的药理特性和低毒性，有望用作食品补充剂或用于制药。
