Tay Andy, Kunze Anja, Murray Coleman, Di Carlo Dino
Department of Bioengineering, ‡California Nanosystems Institute, and §Jonsson Comprehensive Cancer Center, University of California , Los Angeles, California 90025, United States.
ACS Nano. 2016 Feb 23;10(2):2331-41. doi: 10.1021/acsnano.5b07118. Epub 2016 Jan 28.
Nanomagnetic force stimulation with ferromagnetic nanoparticles was found to trigger calcium influx in cortical neural networks without observable cytotoxicity. Stimulated neural networks showed an average of 20% increment in calcium fluorescence signals and a heightened frequency in calcium spiking. These effects were also confined spatially to areas with engineered high magnetic field gradients. Furthermore, blockage of N-type calcium channels inhibited the stimulatory effects of the nanomagnetic forces, suggesting the role of mechano-sensitive ion channels in mediating calcium influx.
研究发现，使用铁磁性纳米颗粒进行纳米磁力刺激可触发皮质神经网络中的钙内流，且未观察到细胞毒性。受刺激的神经网络显示钙荧光信号平均增加20%，钙尖峰频率升高。这些效应在空间上也局限于具有工程化高磁场梯度的区域。此外，N型钙通道的阻断抑制了纳米磁力的刺激作用，表明机械敏感离子通道在介导钙内流中发挥作用。
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