Goto Yoshinori, Wakita Shigenori, Yoshimitsu Masashi, Inagaki Satoko, Kobayashi Takeshi, Kaneko Shuichi
Dept. of Gastroenterology, Kanazawa University Hospital.
Gan To Kagaku Ryoho. 2015 Dec;42(13):2467-70.
A 78-year-old man with advanced gastric cancer was treated with S-1 and oxaliplatin chemotherapy. He developed hiccups and nausea, and was diagnosed with hyponatremia (serum Na: 120 mEq/L) on day 6 of the first treatment course. Because of his increased urinary Na excretion and relatively high ADH values, he was subsequently diagnosed with chemotherapy-induced syndrome of inappropriate secretion of antidiuretic hormone. The patient recovered after an infusion of hypertonic saline. Although S-1 was restarted, hyponatremia did not recur. We suspected adverse drug reactions to ACE inhibitors and K-sparing diuretics in our case of hyponatremia.
一名78岁的晚期胃癌男性患者接受了S-1和奥沙利铂化疗。他出现了打嗝和恶心症状，并在第一个疗程的第6天被诊断为低钠血症（血清钠：120 mEq/L）。由于其尿钠排泄增加且抗利尿激素（ADH）值相对较高，随后他被诊断为化疗引起的抗利尿激素分泌异常综合征。患者在输注高渗盐水后康复。尽管重新开始使用S-1，但低钠血症未复发。在我们这个低钠血症病例中，我们怀疑是对ACE抑制剂和保钾利尿剂的药物不良反应。
