纳米颗粒毒性相关分子机制综述
A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles.
作者信息
Khalili Fard Javad, Jafari Samira, Eghbal Mohammad Ali
机构信息
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran. ; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2015 Nov;5(4):447-54. doi: 10.15171/apb.2015.061. Epub 2015 Nov 30.
In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high surface charge and radical species generation. In this review, a brief key mechanisms involved in toxic effect of NPs are given, followed by the in vitro toxicity assays of NPs and prooxidant effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum dots, gold NPs and silver NPs.
近几十年来，纳米材料的应用在工业和医学领域备受关注。然而，一些报告提到了这些材料对生物系统和细胞成分的不利影响。纳米颗粒（NPs）产生细胞毒性有几种主要机制，如物理化学性质、有毒元素污染、纤维结构、高表面电荷和自由基生成。在本综述中，简要介绍了纳米颗粒毒性作用的关键机制，随后阐述了纳米颗粒的体外毒性测定以及几种纳米颗粒（如碳纳米管、二氧化钛纳米颗粒、量子点、金纳米颗粒和银纳米颗粒）的促氧化作用。
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