Arruda Paulo H E, Madson Darin M, Ramirez Alejandro, Rowe Eric W, Songer J Glenn
Department of Veterinary Diagnostic and Production Animal Medicine (Arruda, Madson, Ramirez, Songer), Biomedical Science Department (Rowe), Veterinary Microbiology and Preventive Medicine Department (Songer), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Can Vet J. 2016 Feb;57(2):183-8.
Although Clostridium difficile infection (CDI) is a common disease in swine, there is a lack of prevention strategies. The objectives of this study were to evaluate: i) the effectiveness of Lactobacillus spp. and ii) non-toxigenic C. difficile (NTCD) as prevention for the development of CDI in piglets. Cesarean-derived piglets (N = 150) were randomly assigned to 6 groups: GROUP 1 - negative control (n = 10); GROUP 2 - NTCD only (n = 13); GROUP 3 - Lactobacillus spp. only (n = 14); GROUP 4 - positive control (challenged with toxigenic C. difficile strain) (n = 35); GROUP 5 - NTCD and challenged with the toxigenic C. difficile strain (n = 34); and GROUP 6 - Lactobacillus spp. and challenged with the toxigenic C. difficile strain (n = 44). Piglets which received NTCD showed lower prevalence of toxin-positive feces, mesocolonic edema, and microscopic lesions compared with positive control piglets. Administration of Lactobacillus spp. did not reveal clear benefits.
尽管艰难梭菌感染（CDI）在猪中是一种常见疾病，但缺乏预防策略。本研究的目的是评估：i）乳酸杆菌属的有效性；ii）非产毒艰难梭菌（NTCD）作为预防仔猪发生CDI的效果。剖腹产仔猪（N = 150）被随机分为6组：第1组 - 阴性对照（n = 10）；第2组 - 仅NTCD（n = 13）；第3组 - 仅乳酸杆菌属（n = 14）；第4组 - 阳性对照（用产毒艰难梭菌菌株攻击）（n = 35）；第5组 - NTCD并用产毒艰难梭菌菌株攻击（n = 34）；第6组 - 乳酸杆菌属并用产毒艰难梭菌菌株攻击（n = 44）。与阳性对照仔猪相比，接受NTCD的仔猪毒素阳性粪便、结肠系膜水肿和微观病变的发生率较低。施用乳酸杆菌属未显示出明显益处。
