Lee Joo-Young, Na Yoon-Ah, Kim Eungsoo, Lee Heung-Shick, Kim Pil
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Department of Biological Engineering, Inha University, Incheon 22212, Republic of Korea.
J Microbiol Biotechnol. 2016 May 28;26(5):807-22. doi: 10.4014/jmb.1601.01053.
Starting as a glutamate producer, Corynebacterium glutamicum has played a variety of roles in the industrial production of amino acids, one of the most important areas of white biotechnology. From shortly after its genome information became available, C. glutamicum has been applied in various production processes for value-added chemicals, fuels, and polymers, as a key organism in industrial biotechnology alongside the surprising progress in systems biology and metabolic engineering. In addition, recent studies have suggested another potential for C. glutamicum as a synthetic biology platform chassis that could move the new era of industrial microbial biotechnology beyond the classical field. Here, we review the recent progress and perspectives in relation to C. glutamicum, which demonstrate it as one of the most promising and valuable workhorses in the field of industrial biotechnology.
谷氨酸棒杆菌最初是作为谷氨酸生产者，在白色生物技术最重要的领域之一——氨基酸的工业生产中发挥了多种作用。自其基因组信息公布后不久，谷氨酸棒杆菌就作为工业生物技术中的关键生物体，与系统生物学和代谢工程领域取得的惊人进展一起，被应用于各种增值化学品、燃料和聚合物的生产过程中。此外，最近的研究表明，谷氨酸棒杆菌作为合成生物学平台底盘还有另一种潜力，这可能会推动工业微生物生物技术新时代超越传统领域。在此，我们回顾了与谷氨酸棒杆菌相关的最新进展和前景，这些进展表明它是工业生物技术领域最有前途和最有价值的主力菌株之一。
