Freires Irlan Almeida, de Alencar Severino Matias, Rosalen Pedro Luiz
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
Department of Agri-food Industry, Food and Nutrition, "Luiz de Queiroz" College of Agriculture, University of São Paulo, Piracicaba, SP, Brazil.
Eur J Med Chem. 2016 Mar 3;110:267-79. doi: 10.1016/j.ejmech.2016.01.033. Epub 2016 Jan 20.
Propolis is a complex resinous mixture collected by bees, with high medicinal, historical and economic value. The nutraceutical and pharmacological benefits of propolis have been extensively explored in several fields of medicine as an important resource for prevention and treatment of oral and systemic diseases. A relatively new type of propolis, named red propolis (in Brazil, Brazilian Red Propolis - BRP), has been arousing attention for the promising pharmacological properties of some of its isolated compounds (vestitol, neovestitol, quercetin, medicarpin, formononetin, etc). Due to a distinct chemical composition, BRP and its isolated compounds (mainly isoflavones) affect a wide range of biological targets and could have an impact against numerous diseases as an antimicrobial, anti-inflammatory and immunomodulatory, antioxidant and antiproliferative agent. In this review, we comprehensively address the main aspects related to BRP bioprospection, chemistry and therapeutic potential. Further information is provided on mechanisms of action discovered thus far as well as clinical use in humans and regulatory aspects. As of now, BRP and its isolated molecules remain a fascinating topic for further research and application in biomedical areas and dentistry.
蜂胶是蜜蜂采集的一种复杂树脂混合物，具有很高的药用、历史和经济价值。作为预防和治疗口腔及全身性疾病的重要资源，蜂胶的营养保健和药理益处已在多个医学领域得到广泛探索。一种相对新型的蜂胶，名为红蜂胶（在巴西称为巴西红蜂胶 - BRP），因其某些分离化合物（红豆衫醇、新红豆衫醇、槲皮素、紫穗槐二氢黄酮、芒柄花素等）具有有前景的药理特性而备受关注。由于其独特的化学成分，BRP及其分离化合物（主要是异黄酮）作用于广泛的生物靶点，作为抗菌、抗炎、免疫调节、抗氧化和抗增殖剂，可能对多种疾病产生影响。在本综述中，我们全面阐述了与BRP生物勘探、化学和治疗潜力相关的主要方面。还提供了迄今为止发现的作用机制以及在人类中的临床应用和监管方面的进一步信息。截至目前，BRP及其分离分子仍然是生物医学领域和牙科进一步研究和应用的一个引人入胜的课题。
