Cui Ming, You Lei, Ren Xiaoxia, Zhao Wenjing, Liao Quan, Zhao Yupei
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union, Medical College, Beijing 100730, China.
Biochem Biophys Res Commun. 2016 Feb 26;471(1):10-4. doi: 10.1016/j.bbrc.2015.12.101. Epub 2016 Feb 3.
Genome-wide sequencing technologies have led to the identification of many non-coding RNAs and revealed an important role for these molecules in cancer. Although there have been many studies on the role of short non-coding RNAs in cancer, much work remains to characterize the functions of long non-coding RNAs. PVT1, a long non-coding RNA encoded by the human PVT1 gene, is located in the well-known cancer-related region 8q24, also known as the 8q24 'gene desert.' PVT1 has three main molecular mechanisms of action: participating in DNA rearrangements, encoding microRNAs, and interacting with MYC. Studies on the association between PVT1 and cancer have shown that PVT1 is a potential oncogene in a variety of cancer types. However, the underlying molecular mechanisms of PVT1 in cancer remain unknown. Further studies of PVT1 will be required to test the utility of this molecule as a target for cancer diagnosis and therapy, and they should also increase our understanding of the role of long non-coding RNAs in tumorigenesis.
全基因组测序技术已促使许多非编码RNA得以鉴定，并揭示了这些分子在癌症中发挥的重要作用。尽管已有许多关于短链非编码RNA在癌症中作用的研究，但仍有大量工作有待开展，以明确长链非编码RNA的功能。PVT1是一种由人类PVT1基因编码的长链非编码RNA，位于著名的癌症相关区域8q24，也被称为8q24“基因荒漠”。PVT1有三种主要的作用分子机制：参与DNA重排、编码微小RNA以及与MYC相互作用。关于PVT1与癌症关联的研究表明，PVT1在多种癌症类型中是一种潜在的癌基因。然而，PVT1在癌症中的潜在分子机制仍不清楚。需要对PVT1进行进一步研究，以测试该分子作为癌症诊断和治疗靶点的效用，同时这些研究也应增进我们对长链非编码RNA在肿瘤发生中作用的理解。
