Whitman Mary C, MacNeill Katelyn, Hunter David G
Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts.
Ophthalmology. 2016 Apr;123(4):690-6. doi: 10.1016/j.ophtha.2015.12.025. Epub 2016 Feb 4.
To assess whether stereopsis outcomes of patients with accommodative esotropia with high accommodative convergence/accommodation relationship (AC/A) were improved after treatment with bifocal glasses compared with single-vision lenses.
Retrospective cohort study.
Patients with high AC/A accommodative esotropia; evidence of stereopsis, binocularity (on Worth 4-dot testing), or improvement in near angle with +3.00 D lenses; and at least 4 years of records available for review, who were seen in the Department of Ophthalmology at Boston Children's Hospital between 2006 and 2014.
Use of bifocal or single-vision glasses. Charts were reviewed retrospectively. Stereopsis was log transformed for statistical analysis. Linear (for stereopsis) or logistic (for surgery) regression was used to control for confounders.
Stereopsis at final follow-up, difference in stereopsis between final and initial visits, and progression to strabismus surgery. Secondary outcomes included final near and distance deviations.
Of the 180 patients who met inclusion criteria, 77 used bifocals and 103 used single-vision lenses. Bifocals did not improve stereopsis outcomes compared with single-vision lenses. In both groups, stereopsis was similar at the initial and final visits, with similar improvement in both groups. Children in the bifocal group had a 3.6-fold higher rate of strabismus surgery than children in the single-lens group (P = 0.04.) Additionally, children in the bifocal group had near deviations 4 PD larger than those with single lenses at final follow-up, even after controlling for age and initial deviation (P = 0.02). These results did not change if surgical patients were eliminated or in the subgroup with initial distance deviation of 0 PD in full hyperopic correction.
Despite their widespread use, there is no evidence that bifocals improve outcomes in children with accommodative esotropia with high AC/A. In our retrospective review, children with bifocals had higher surgical rates and a smaller improvement in near deviation over time. Although our results suggest that eliminating bifocals could reduce the cost and complexity of care while potentially improving quality, prospective, randomized controlled trials are needed to determine whether a change in practice is warranted.
评估与单焦点镜片相比,双焦点眼镜治疗高调节性集合/调节关系(AC/A)的调节性内斜视患者后,其立体视功能结果是否得到改善。
回顾性队列研究。
高AC/A调节性内斜视患者;有立体视、双眼视(Worth 4点试验)证据,或使用+3.00 D镜片时近斜视角度有改善;且有至少4年可供查阅记录,于2006年至2014年期间在波士顿儿童医院眼科就诊的患者。
使用双焦点或单焦点眼镜。对病历进行回顾性分析。对立体视进行对数转换以进行统计分析。使用线性(针对立体视)或逻辑(针对手术)回归来控制混杂因素。
最终随访时的立体视、最终与初次就诊时立体视的差异以及斜视手术进展情况。次要结局包括最终的近斜视和远斜视偏差。
在符合纳入标准的180例患者中,77例使用双焦点眼镜,103例使用单焦点镜片。与单焦点镜片相比,双焦点眼镜并未改善立体视功能结果。两组在初次和最终就诊时立体视相似,两组改善情况相近。双焦点眼镜组儿童斜视手术发生率比单焦点镜片组儿童高3.6倍(P = 0.04)。此外,即使在控制年龄和初始偏差后,双焦点眼镜组儿童在最终随访时的近斜视偏差比单焦点镜片组儿童大4棱镜度(P = 0.02)。如果剔除手术患者或在初始远斜视偏差为0棱镜度的完全远视矫正亚组中,这些结果并无改变。
尽管双焦点眼镜被广泛使用,但没有证据表明其能改善高AC/A调节性内斜视儿童的治疗效果。在我们的回顾性研究中,使用双焦点眼镜的儿童手术率更高,且随着时间推移近斜视偏差改善较小。尽管我们的结果表明摒弃双焦点眼镜可能会降低护理成本和复杂性,同时潜在地提高质量,但仍需要进行前瞻性随机对照试验来确定是否有必要改变治疗方法。