Payão Spencer Luiz Marques, Rasmussen Lucas Trevizani
Spencer Luiz Marques Payão, Laboratório de Genética, Hemocentro, Marília Medical School, FAMEMA, São Paulo, CEP 17519-050, Brazil.
World J Gastrointest Pharmacol Ther. 2016 Feb 6;7(1):126-32. doi: 10.4292/wjgpt.v7.i1.126.
Helicobacter pylori (H. pylori) has long been found to cause gastric diseases such as gastritis, gastric ulcers and gastric cancer. The transmission medium of this bacterium has yet to be determined, though several studies have speculated that the oral cavity is a reservoir for H. pylori. Others have also reported that the oral cavity may be a source of both transmission and gastric reinfection; however, such results are controversial. We reviewed the literature and selected studies that report an association among H. pylori detections in the oral cavity (dental plaque, saliva, tongue, tonsil tissue, root canals, oral mucosa) in humans and in animals, as well as in the human stomach. The oral cavity may be considered the main reservoir for H. pylori. There are a correlations between H. pylori infection in the oral cavity and periodontal disease, oral tissue inflammation, H. pylori transmission, and gastric reinfection. We believe that the mouth is a reservoir and that it plays a crucial role in both H. pylori transmission and gastric infection.
长期以来，人们发现幽门螺杆菌（H. pylori）会引发胃炎、胃溃疡和胃癌等胃部疾病。尽管多项研究推测口腔是幽门螺杆菌的储存库，但这种细菌的传播媒介尚未确定。也有其他研究报告称，口腔可能是传播和胃部再次感染的源头；然而，这些结果存在争议。我们回顾了文献，并挑选出了一些研究，这些研究报告了在人类、动物的口腔（牙菌斑、唾液、舌头、扁桃体组织、根管、口腔黏膜）以及人类胃部中检测到幽门螺杆菌之间的关联。口腔可能被视为幽门螺杆菌的主要储存库。口腔中的幽门螺杆菌感染与牙周病、口腔组织炎症、幽门螺杆菌传播以及胃部再次感染之间存在相关性。我们认为口腔是一个储存库，并且它在幽门螺杆菌传播和胃部感染中都起着至关重要的作用。
