应用于膜蛋白的生物物理电子顺磁共振研究。
Biophysical EPR Studies Applied to Membrane Proteins.
作者信息
Sahu Indra D, Lorigan Gary A
机构信息
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, United States of America.
出版信息
J Phys Chem Biophys. 2015;5(6). doi: 10.4172/2161-0398.1000188. Epub 2015 Oct 15.
Abstract
Membrane proteins are very important in controlling bioenergetics, functional activity, and initializing signal pathways in a wide variety of complicated biological systems. They also represent approximately 50% of the potential drug targets. EPR spectroscopy is a very popular and powerful biophysical tool that is used to study the structural and dynamic properties of membrane proteins. In this article, a basic overview of the most commonly used EPR techniques and examples of recent applications to answer pertinent structural and dynamic related questions on membrane protein systems will be presented.
摘要
膜蛋白在控制生物能量学、功能活性以及启动各种复杂生物系统中的信号通路方面非常重要。它们还约占潜在药物靶点的50%。电子顺磁共振光谱是一种非常流行且强大的生物物理工具，用于研究膜蛋白的结构和动力学特性。本文将对最常用的电子顺磁共振技术进行基本概述，并给出近期应用实例，以解答有关膜蛋白系统的相关结构和动力学问题。
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