Schalk K P, Rüterjans H, Kaltwasser J P, Said l-Hadj H, Staffenberger L
Abteilung für Hämatologie, Johann-Wolfgang-Goethe-Universität, Frankfurt.
Onkologie. 1989 Aug;12 Suppl 1:5-8. doi: 10.1159/000216676.
One year ago a new specific test for the detection of cancer was presented. The authors described a new method to measure the line width of lipoproteins in plasma by NMR-spectroscopy. Their results showed a significant decrease of the line width in plasma of patients with cancer compared to normals. The present study gives the results of a cooperative investigation in our institutes to prove the reliability of the so-called Fossel test. We investigated 100 samples, including 27 healthy persons, 13 pregnant women, 13 patients with non malignant and 47 patients with malignant disease without any tumor treatment. Blood samples were drawn after an overnight fasting and EDTA plasma was stored at -18 degrees C NMR spectroscopy was performed by an AM Spectrometer by using deuteriumoxide and water suppression by a decoupling power of 9 L. The mean line width was found 41.07 +/- 6.08 Hz for healthy and 34.40 +/- 10.80 for patients with non malignant diseases. Patients with cancer and other hematological diseases showed a mean of 35.40 +/- 8.0 Hz. Only in pregnancy a significant decrease of the line width (mean 32.60 +/- 5.7 Hz) was observed. Only small differences between normals, patients with cancer and patients with non malignant disease could be found. The wide range of the line width did not allow any discrimination between malignant and non malignant disease.
一年前，一种用于检测癌症的新型特异性检测方法问世。作者描述了一种通过核磁共振光谱法测量血浆中脂蛋白谱线宽度的新方法。他们的结果显示，与正常人相比，癌症患者血浆中的谱线宽度显著降低。本研究给出了我们各研究所合作调查的结果，以证明所谓的福塞尔检测的可靠性。我们调查了100个样本，包括27名健康人、13名孕妇、13名非恶性疾病患者和47名未经任何肿瘤治疗的恶性疾病患者。空腹过夜后采集血样，将乙二胺四乙酸血浆储存在-18摄氏度。使用AM光谱仪通过氧化氘进行核磁共振光谱分析，并通过9L的去耦功率抑制水峰。健康人的平均谱线宽度为41.07±6.08Hz，非恶性疾病患者为34.40±10.80Hz。癌症患者和其他血液疾病患者的平均值为35.40±8.0Hz。仅在孕期观察到谱线宽度显著降低（平均值为32.60±5.7Hz）。在正常人、癌症患者和非恶性疾病患者之间仅发现了微小差异。谱线宽度的广泛范围不允许对恶性和非恶性疾病进行任何区分。
