Yoshimi H, Hirata Y, Fukuda Y, Kawano Y, Emori T, Kuramochi M, Omae T, Marumo F
Hypertension-Endocrine Division, National Cardiovascular Center Research Institute and Hospital, Osaka, Japan.
Peptides. 1989 Jul-Aug;10(4):805-8. doi: 10.1016/0196-9781(89)90117-4.
By use of a specific radioimmunoassay for endothelin (ET), the regional distribution of ET-like immunoreactivity (LI) was studied in rats. The antiserum used cross-reacted equally with synthetic porcine and rat ET. Significant amounts of ET-LI are detectable not only in aorta, but also in kidney, lung, heart, liver and central nervous system. Gel chromatography of the tissue extracts revealed size heterogeneity of ET-LI; one major component eluting close to, but slightly larger than standard rat ET and the other minor component with a larger molecular weight. These data indicate that ET-LI is widely distributed throughout the various rat tissues, suggesting its possible involvement in a variety of organ functions.
