通过小鼠骨髓瘤细胞与致敏脾细胞之间的体细胞杂交产生抗流感病毒抗体。
Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells.
作者信息
Koprowski H, Gerhard W, Croce C M
出版信息
Proc Natl Acad Sci U S A. 1977 Jul;74(7):2985-8. doi: 10.1073/pnas.74.7.2985.
Abstract
We have produced somatic cell hybrids between mouse myeloma cells and spleen cells derived from a BALB/c mouse immunized with purified influenza virus. The hybrid cells were found to produce large amounts of antibodies specific for the hemagglutinin of the virus and were able to induce tumor formation when injected into BALB/c mice.
摘要
我们已经在小鼠骨髓瘤细胞与源自用纯化流感病毒免疫的BALB/c小鼠的脾细胞之间产生了体细胞杂种。发现这些杂种细胞能产生大量针对该病毒血凝素的特异性抗体，并且当注入BALB/c小鼠体内时能够诱导肿瘤形成。
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