植物中的RNA干扰：以AGO蛋白为中心的视角
RNAi in Plants: An Argonaute-Centered View.
作者信息
Fang Xiaofeng, Qi Yijun
机构信息
Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China Tsinghua-Peking Center for Life Sciences, Beijing 100084, China
出版信息
Plant Cell. 2016 Feb;28(2):272-85. doi: 10.1105/tpc.15.00920. Epub 2016 Feb 11.
Abstract
Argonaute (AGO) family proteins are effectors of RNAi in eukaryotes. AGOs bind small RNAs and use them as guides to silence target genes or transposable elements at the transcriptional or posttranscriptional level. Eukaryotic AGO proteins share common structural and biochemical properties and function through conserved core mechanisms in RNAi pathways, yet plant AGOs have evolved specialized and diversified functions. This Review covers the general features of AGO proteins and highlights recent progress toward our understanding of the mechanisms and functions of plant AGOs.
摘要
Argonaute（AGO）家族蛋白是真核生物中RNA干扰的效应因子。AGO蛋白结合小RNA，并将它们作为指导，在转录或转录后水平沉默靶基因或转座元件。真核生物AGO蛋白具有共同的结构和生化特性，并通过RNA干扰途径中的保守核心机制发挥作用，然而植物AGO蛋白已经进化出专门且多样的功能。本综述涵盖了AGO蛋白的一般特征，并着重介绍了我们在理解植物AGO蛋白的机制和功能方面的最新进展。
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