Alsahafi Abdullah J, Cheng Allen C
Department of Epidemiology and Preventive Medicine, Monash University, Alfred Centre, 99 Commercial Rd, Melbourne, VIC 3004, Australia.
Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Australia.
Int J Infect Dis. 2016 Apr;45:1-4. doi: 10.1016/j.ijid.2016.02.004. Epub 2016 Feb 10.
The aim of this study was to review the epidemiology of cases of Middle East respiratory syndrome coronavirus (MERS-CoV) reported in the Kingdom of Saudi Arabia from 2012 when the first MERS-CoV was confirmed up to July 2015.
MERS-CoV data were obtained from the Saudi Ministry of Health for the period 2012 to July 2015. Descriptive statistics were used to summarize the results regarding the risk factors and mortality of MERS-CoV infection.
In this series, the risk factors and outcomes of 939 cases of MERS-CoV occurring in the last 3 years are described. The majority of the affected patients were aged ≥40 years (n=657; 70%). Of the 657 patients aged ≥40 years, 377 (57.3%) died.
The case-fatality ratio was found to increase significantly with age. It ranged from 12.5% in those aged ≤19 years to 86.2% in those aged ≥80 years. The results confirmed the association between severe MERS-CoV illness and patients with a pre-existing health morbidity. The duration from symptom onset to admission was not statistically associated with the disease outcome.
本研究旨在回顾沙特阿拉伯王国自2012年首例中东呼吸综合征冠状病毒（MERS-CoV）确诊至2015年7月期间报告的MERS-CoV病例的流行病学情况。
获取沙特卫生部2012年至2015年7月期间的MERS-CoV数据。采用描述性统计方法总结MERS-CoV感染的危险因素和死亡率相关结果。
在本系列研究中，描述了过去3年中939例MERS-CoV病例的危险因素和转归情况。大多数受影响患者年龄≥40岁（n = 657；70%）。在657例年龄≥40岁的患者中，377例（57.3%）死亡。
发现病死率随年龄显著增加。年龄≤19岁者病死率为12.5%，年龄≥80岁者病死率为86.2%。结果证实了严重MERS-CoV疾病与已有健康问题的患者之间的关联。症状出现至入院的时间与疾病转归无统计学关联。
