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在黑猩猩(Pan troglodytes)中使用植入式循环记录仪监测心律失常并评估针灸和激光治疗的效果。

Use of an Implantable Loop Recorder in a Chimpanzee (Pan troglodytes) to Monitor Cardiac Arrhythmias and Assess the Effects of Acupuncture and Laser Therapy.

作者信息

Magden Elizabeth R, Sleeper Meg M, Buchl Stephanie J, Jones Rebekah A, Thiele Erica J, Wilkerson Gregory K

机构信息

Michale E Keeling Center for Comparative Medicine and Research, Department of Veterinary Sciences, MD Anderson Cancer Center, Bastrop, Texas, USA.

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

出版信息

Comp Med. 2016 Feb;66(1):52-8.

Abstract

Cardiovascular disease is a leading cause of death in captive chimpanzees and is often associated with myocardial fibrosis, which increases the risk of cardiac arrhythmias. In this case report, we present a 36-y-old male chimpanzee (Pan troglodytes) diagnosed with frequent ventricular premature complexes (VPC). We placed a subcutaneous implantable loop recorder for continual ECG monitoring to assess his arrhythmias without the confounding effects of anesthetics. During his initial treatment with the antiarrhythmia medication amiodarone, he developed thrombocytopenia, and the drug was discontinued. After reviewing other potential therapies for the treatment of cardiac arrhythmias, we elected to try acupuncture and laser therapy in view of the positive results and the lack of adverse side effects reported in humans. We used 2 well-known cardiac acupuncture sites on the wrist, PC6 (pericardium 6) and HT7 (heart 7), and evaluated the results of the therapy by using the ECG recordings from the implantable loop recorder. Although periodic increases in the animal's excitement level introduced confounding variables that caused some variation in the data, acupuncture and laser therapy appeared to decrease the mean number of VPC/min in this chimpanzee.

摘要

心血管疾病是圈养黑猩猩死亡的主要原因,且常常与心肌纤维化有关,而心肌纤维化会增加心律失常的风险。在本病例报告中,我们介绍了一只36岁的雄性黑猩猩(黑猩猩属),它被诊断为频发室性早搏(VPC)。我们植入了皮下可植入式环路记录器以持续进行心电图监测,从而在无麻醉干扰的情况下评估其心律失常情况。在最初使用抗心律失常药物胺碘酮进行治疗期间,它出现了血小板减少症,于是停用了该药物。在评估了其他治疗心律失常的潜在疗法后,鉴于在人类身上报告的积极效果以及缺乏不良副作用,我们选择尝试针灸和激光疗法。我们使用了手腕上两个著名的心脏针灸穴位,内关穴(心包经6)和神门穴(心经7),并通过可植入式环路记录器记录的心电图来评估治疗效果。尽管动物兴奋水平的周期性升高引入了混杂变量,导致数据出现一些变化,但针灸和激光疗法似乎减少了这只黑猩猩的平均室性早搏次数/分钟。

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