Chowdhury Goutam, Joshi Sangeeta, Bhattacharya Sanjay, Sekar Uma, Birajdar Balaji, Bhattacharyya Arpita, Shinoda Sumio, Ramamurthy Thandavarayan
Department of Bacteriology, National Institute of Cholera and Enteric Diseases Kolkata, India.
Manipal Hospital Bangalore, India.
Front Microbiol. 2016 Feb 11;7:144. doi: 10.3389/fmicb.2016.00144. eCollection 2016.
Vibrio cholerae is an aerobic, sucrose fermentative Gram-negative bacterium that generally prevails in the environment. Pathogenic V. cholerae is well-known as causative agent of acute diarrhea. Apart from enteric infections, V. cholerae may also cause other diseases. However, their role in causing extraintestinal infections is not fully known as it needs proper identification and evaluation. Four cases of extraintestinal infections due to V. cholerae non-O1/non-O139 have been investigated. The isolates were screened for phenotypic and genetic characteristics with reference to their major virulence genes. Serologically distinct isolates harbored rtx, msh, and hly but lacked enteric toxin encoding genes that are generally present in toxigenic V. cholerae. Timely detection of this organism can prevent fatalities in hospital settings. The underlying virulence potential of V. cholerae needs appropriate testing and intervention.
霍乱弧菌是一种需氧、能发酵蔗糖的革兰氏阴性菌，普遍存在于环境中。致病性霍乱弧菌是急性腹泻的著名病原体。除肠道感染外，霍乱弧菌还可能引起其他疾病。然而，它们在引起肠外感染中的作用尚未完全明确，因为这需要进行适当的鉴定和评估。已对4例由非O1/非O139霍乱弧菌引起的肠外感染进行了调查。参照其主要毒力基因，对分离株进行了表型和基因特征筛选。血清学上不同的分离株携带rtx、msh和hly基因，但缺乏产毒霍乱弧菌中通常存在的肠毒素编码基因。及时检测这种细菌可预防医院环境中的死亡。霍乱弧菌潜在的毒力需要进行适当的检测和干预。
