Rummun Nawraj, Somanah Jhoti, Ramsaha Srishti, Bahorun Theeshan, Neergheen-Bhujun Vidushi S
Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius.
Department of Biosciences, and ANDI Centre of Excellence for Biomedical and Biomaterials Research, University of Mauritius, Réduit, Mauritius.
Int J Food Sci. 2013;2013:602312. doi: 10.1155/2013/602312. Epub 2013 Jul 8.
Punica granatum L. has a long standing culinary and medicinal traditional use in Mauritius. This prompted a comparative study to determine the bioefficacy of the flower, peel, leaf, stem, and seed extracts of the Mauritian P. granatum. The flower and peel extracts resulting from organic solvent extraction exhibited strong antioxidant activities which correlated with the high levels of total phenolics, flavonoids, and proanthocyanidins. The peel extract had the most potent scavenging capacity reflected by high Trolox equivalent antioxidant capacity value (5206.01 ± 578.48 μmol/g air dry weight), very low IC50 values for hypochlorous acid (0.004 ± 0.001 mg air dry weight/mL), and hydroxyl radicals scavenging (0.111 ± 0.001 mg air dry weight/mL). Peel extracts also significantly inhibited S. mutans (P < 0.001), S. mitis (P < 0.001), and L. acidophilus (P < 0.05) growth compared to ciprofloxacin. The flower extract exhibited high ferric reducing, nitric oxide scavenging, and iron (II) ions chelation and significantly inhibited microsomal lipid peroxidation. Furthermore, it showed a dose-dependent inhibition of xanthine oxidase with an IC50 value of 0.058 ± 0.011 mg air dry weight/mL. This study showed that nonedible parts of cultivated pomegranates, that are generally discarded, are bioactive in multiassay systems thereby suggesting their potential use as natural prophylactics and in food applications.
在毛里求斯，石榴长期以来一直被用于烹饪和药用。这促使人们进行了一项比较研究，以确定毛里求斯石榴的花、果皮、叶、茎和种子提取物的生物功效。有机溶剂萃取得到的花和果皮提取物表现出较强的抗氧化活性，这与总酚、黄酮类化合物和原花青素的高含量相关。果皮提取物具有最强的清除能力，其特罗克斯当量抗氧化能力值较高（5206.01±578.48μmol/g风干重量），次氯酸清除的IC50值极低（0.004±0.001mg风干重量/mL），羟基自由基清除能力为（0.111±0.001mg风干重量/mL）。与环丙沙星相比，果皮提取物还能显著抑制变形链球菌（P<0.001）、缓症链球菌（P<0.001）和嗜酸乳杆菌（P<0.05）的生长。花提取物表现出较高的铁还原、一氧化氮清除和铁（II）离子螯合能力，并能显著抑制微粒体脂质过氧化。此外，它对黄嘌呤氧化酶有剂量依赖性抑制作用，IC50值为0.058±0.011mg风干重量/mL。这项研究表明，栽培石榴通常被丢弃的不可食用部分在多种检测系统中具有生物活性，因此表明它们有作为天然预防剂和用于食品应用的潜力。
