Wilson Kumanan, Atkinson Katherine M, Westeinde Jacqueline, Bell Cameron, Marty Kim, Fergusson Dean, Deeks Shelley L, Crowcroft Natasha, Bettinger Julie A
a Clinical Epidemiology Program; Ottawa Hospital Research Institute ; Ottawa , Canada.
b Department of Medicine ; University of Ottawa ; Ottawa , Canada.
Hum Vaccin Immunother. 2016 Jul 2;12(7):1738-48. doi: 10.1080/21645515.2016.1152434. Epub 2016 Feb 23.
The Canadian National Vaccine Safety network (CANVAS) gathers and analyzes safety data on individuals receiving the influenza vaccine during the early stages of annual influenza vaccination campaigns with data collected via participant surveys through the Internet. We sought to examine whether it was feasible to use a mobile application (app) to facilitate AEFI reporting for the CANVAS network. To explore this, we developed a novel smartphone app, recruited participants from a hospital influenza immunization clinic and by word of mouth and instructed them to download and utilize the app. The app reminded participants to complete the CANVAS AEFI surveillance surveys ("AEFI surveys") on day 8 and 30, a survey capturing app usability metrics at day 30 ("usability survey") and provided a mechanism to report AEFI events spontaneously throughout the whole study period. All survey results and spontaneous reports were recorded on a privacy compliant, cloud server. A software plug-in, Lookback, was used to record the on-screen experience of the app sessions. Of the 76 participants who consented to participate, 48(63%) successfully downloaded the app and created a profile. In total, 38 unique participants completed all of the required surveillance surveys; transmitting 1104 data points (survey question responses and spontaneous reports) from 83 completed surveys, including 21 usability surveys and one spontaneous report. In total, we received information on new or worsening health conditions after receiving the influenza vaccine from 11(28%) participants. Of the usability survey responses, 86% agreed or strongly agreed that they would prefer to use a mobile app based reporting system instead of a web-based system. The single spontaneous report received was from a participant who had also reported using the Day 8 survey. Of Lookback observable sessions, an accurate transmission proportion of 100% (n=290) was reported for data points. We demonstrated that a mobile app can be used for AEFI reporting, although download and survey completion proportions suggest potential barriers to adoption. Future studies should examine implementation of mobile reporting in a broader audience and impact on the quality of reporting of adverse events following immunization.
加拿大国家疫苗安全网络（CANVAS）在年度流感疫苗接种活动的早期阶段，通过互联网参与者调查收集的数据，收集并分析接种流感疫苗个体的安全数据。我们试图研究使用移动应用程序（应用）来促进CANVAS网络的疑似预防接种异常反应（AEFI）报告是否可行。为了探究这一点，我们开发了一款新型智能手机应用，通过医院流感免疫诊所并口口相传招募参与者，并指导他们下载和使用该应用。该应用提醒参与者在第8天和第30天完成CANVAS AEFI监测调查（“AEFI调查”），在第30天进行一项收集应用可用性指标的调查（“可用性调查”），并提供一种机制，以便在整个研究期间自发报告AEFI事件。所有调查结果和自发报告都记录在一个符合隐私规定的云服务器上。使用一个名为Lookback的软件插件来记录应用会话的屏幕体验。在同意参与的76名参与者中，48名（63%）成功下载了应用并创建了个人资料。总共有38名不同的参与者完成了所有所需的监测调查；从83份完成的调查中传输了1104个数据点（调查问题回答和自发报告），包括21份可用性调查和1份自发报告。总共有11名（28%）参与者在接种流感疫苗后提供了有关新的或病情加重的健康状况信息。在可用性调查回复中，86%的人同意或强烈同意他们更愿意使用基于移动应用的报告系统而不是基于网络的系统。收到的唯一一份自发报告来自一名也在第8天调查中报告过的参与者。对于Lookback可观察到的会话，报告的数据点准确传输比例为100%（n = 290）。我们证明了移动应用可用于AEFI报告，尽管下载和调查完成比例表明存在采用方面的潜在障碍。未来的研究应考察在更广泛人群中实施移动报告的情况以及对免疫接种后不良事件报告质量的影响。
