利用铜的氧化还原反应进行基于 (19)F 磁共振的细胞缺氧检测。
Exploiting Copper Redox for (19)F Magnetic Resonance-Based Detection of Cellular Hypoxia.
机构信息
Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
出版信息
J Am Chem Soc. 2016 Mar 9;138(9):2937-40. doi: 10.1021/jacs.5b13215. Epub 2016 Feb 26.
We report a pair of fluorinated, redox-active copper complexes for potential use as (19)F MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched (19)F NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F3 resulted in a selective detection of (19)F signal in cells grown under hypoxic conditions.
我们报告了一对氟化的、氧化还原活性的铜配合物，可作为（19）F MRI 对比剂，用于检测细胞缺氧。三氟化铜（II）ATSM-F3 具有合适的氧化还原电位，可选择性地在缺氧细胞中积累，并在还原为铜（I）后完全猝灭（19）F NMR 信号。将 CuATSM-F3 孵育癌细胞，可选择性地检测在缺氧条件下生长的细胞中的（19）F 信号。
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