Kim Joon Young, DeMenna Jacob T, Puppala Sobha, Chittoor Geetha, Schneider Jennifer, Duggirala Ravindranath, Mandarino Lawrence J, Shaibi Gabriel Q, Coletta Dawn K
Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA.
College of Health Solutions, School for the Science of Health Care Delivery, Arizona State University, 550N. 3rd Street, Phoenix, 85004, AZ, USA.
BMC Genet. 2016 Feb 24;17:47. doi: 10.1186/s12863-016-0357-6.
Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA influences and interactive effects between FTO variants and PA on measures of adiposity in Latinos.
After controlling for age and sex, participants who did not engage in regular PA exhibited higher BMI, fat mass, HC, and WC with statistical significance (P < 0.001). Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations. However, several of such interactive influences exhibited considerable trend towards association.
These data suggest that adiposity measures are associated with PA and FTO variants in Latinos, but the impact of their interactive influences on these obesity measures appear to be minimal. Future studies with large sample sizes may help to determine whether individuals with specific FTO variants exhibit differential responses to PA interventions.
尽管脂肪量和肥胖相关（FTO）基因对肥胖的影响已得到充分证实，但缺乏证据表明身体活动（PA）是否会改变FTO变异对拉丁裔人群肥胖的影响。因此，本研究的目的是探讨PA的影响以及FTO变异与PA之间对拉丁裔人群肥胖指标的交互作用。
在控制年龄和性别后，未进行规律PA的参与者的体重指数（BMI）、脂肪量、臀围（HC）和腰围（WC）显著更高（P < 0.001）。尽管发现三种FTO基因型与肥胖指标之间存在显著关联，但FTO基因型与PA交互作用评估均未显示出名义上的显著关联。然而，其中一些交互影响呈现出相当明显的关联趋势。
这些数据表明，拉丁裔人群的肥胖指标与PA和FTO变异有关，但其交互作用对这些肥胖指标的影响似乎很小。未来大样本量的研究可能有助于确定具有特定FTO变异的个体对PA干预是否表现出不同反应。
