Qiao Jian, Liu Zhida, Fu Yang-Xin
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Department of Pathology, University of Chicago, Chicago, Illinois, USA.
J Mol Med (Berl). 2016 May;94(5):489-95. doi: 10.1007/s00109-016-1393-4. Epub 2016 Feb 24.
The efficacy of directly killing tumors by conventional cancer therapies, such as chemotherapy and radiotherapy, has been for several decades well established. But, a suppressed immune response might become a lethal side effect after repeated cycles of intensive treatment. Recently, achievements in immune checkpoint inhibitors and adoptive T cell-mediated immunotherapies have resulted in changes in frontline management of advanced cancer diseases. However, accumulated evidence indicates that immunotherapeutic and conventional strategies alone are often ineffective to eradicate big tumors or metastasis. To improve the outcomes of treatment for advanced cancer diseases, the combination of conventional cancer treatment with various immunotherapeutic approaches has been attempted and has shown potential synergistic effects. Recent studies have unexpectedly demonstrated that some strategies of conventional cancer treatment can regulate the immune response positively, thus the understanding of how to adapt conventional treatment for immunotherapy is crucial to the design of effective combination therapy of conventional treatment with immunotherapy. Here, we review both experimental and clinical studies on the therapeutic effect and its mechanisms of combining conventional therapy with immunotherapy in treatment of cancer.
几十年来，化疗和放疗等传统癌症疗法直接杀伤肿瘤的疗效已得到充分证实。但是，在反复进行强化治疗后，免疫反应受到抑制可能会成为一种致命的副作用。近年来，免疫检查点抑制剂和过继性T细胞介导的免疫疗法取得的进展已使晚期癌症疾病的一线治疗发生了变化。然而，越来越多的证据表明，单独的免疫治疗和传统策略往往无法有效根除大肿瘤或转移灶。为了改善晚期癌症疾病的治疗效果，人们尝试将传统癌症治疗与各种免疫治疗方法相结合，并已显示出潜在的协同效应。最近的研究意外地表明，一些传统癌症治疗策略可以正向调节免疫反应，因此了解如何使传统治疗适应免疫治疗对于设计传统治疗与免疫治疗的有效联合疗法至关重要。在此，我们综述了关于传统疗法与免疫疗法联合治疗癌症的治疗效果及其机制的实验和临床研究。
