Mozumder Mohammad Sayem, Mairpady Anusha, Mourad Abdel-Hamid I
Chemical & Petroleum Engineering Department, UAE University, Al Ain, UAE.
Mechanical Engineering Department, UAE University, Al Ain, P.O. Box 15551, UAE.
J Biomed Mater Res B Appl Biomater. 2017 Jul;105(5):1241-1259. doi: 10.1002/jbm.b.33633. Epub 2016 Feb 23.
Polymeric nanobiocomposites have recently become one of the most essential sought after materials for biomedical applications ranging from implants to the creation of gels. Their unique mechanical and biological properties provide them the ability to pass through the highly guarded defense mechanism without undergoing noticeable degradation and initiation of immune responses, which in turn makes them advantageous over the other alternatives. Aligned with the advances in tissue engineering, it is also possible to design three-dimensional extracellular matrix using these polymeric nanobiocomposites that could closely mimic the human tissues. In fact, unique polymer chemistry coupled with nanoparticles could create unique microenvironment that promotes cell growth and differentiation. In addition, the nanobiocomposites can also be devised to carry drugs efficiently to the target site without exhibiting any cytotoxicity as well as to eradicate surgical infections. In this article, an effort has been made to thoroughly review a number of different types/classes of polymeric nanocomposites currently used in biomedical fields. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1241-1259, 2017.
聚合物纳米生物复合材料最近已成为生物医学应用中最受追捧的重要材料之一，其应用范围涵盖从植入物到凝胶的制备。它们独特的机械和生物学特性使它们能够穿过高度严密的防御机制，而不会发生明显降解或引发免疫反应，这反过来又使它们比其他替代品更具优势。随着组织工程的进展，利用这些聚合物纳米生物复合材料设计出能够紧密模拟人体组织的三维细胞外基质也是可行的。事实上，独特的聚合物化学与纳米颗粒相结合可以创造出促进细胞生长和分化的独特微环境。此外，纳米生物复合材料还可以被设计成能够有效地将药物输送到靶位点，而不表现出任何细胞毒性，以及消除手术感染。在本文中，我们努力全面回顾了目前生物医学领域中使用的多种不同类型/类别的聚合物纳米复合材料。© 2016威利期刊公司。《生物医学材料研究杂志》B部分：应用生物材料，105B: 1241 - 1259, 2017。
