Ghaleh Bandi Mir Farhad, Naserbakht Morteza, Tabasi Abdolreza, Marghaiezadeh Azin, Riazee Esfahani Mohammad, Golzarian Zohre
MD, Associate Professor of Psychiatry, Sleep Medicine Fellowship, Department of Psychiatry, Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
MD, MPH, Assistant Professor of Social Medicine, Mental Health Research Center, Iran University of Medical sciences, Tehran, Iran.
Med J Islam Repub Iran. 2015 Nov 22;29:300. eCollection 2015.
Sleep apnea is temporary cessation or absence of breathing during sleep. Significant increase in blood pressure is clinically seen in apneic episodes. The aim of this study was to examine sleep apnea syndrome as a risk factor for non- arthritic anterior ischemic optic neuropathy (NAION) in a case control study.
Nineteen NAION patients (9 men and 10 women) and 31 age and sex matched control participants (18 men and 13 women) were evaluated for obstructive sleep apnea syndrome (OSAS). Full night polysomnography was performed and proportion of OSAS was compared between the NAION patients and the control group. Other risk factors for NAION such as hypertension, diabetes, hyperlipidemia, ischemic heart disease and tobacco consumption were also evaluated. Chi square test and independent samples t-test were used for statistical analysis.
OF the 19 NAION patients, 18 (95%) had OSAS, and of the control group 13 (41.9%) had OSAS. The frequency of OSAS was significantly higher among NAION patients compared to the controls (p< 0.001). The Mean Respiratory Disturbance Index (RDI) was 37.65/h SD= 37.61/h in NAION patients and it was 15.05/h SD= 11.97/h (p= 0.018) in controls. The frequency of diabetes and hypertension was significantly higher in the NAION patients than in controls.
based on the results of this study, it seems that there is an association between NAION and OSAS.
睡眠呼吸暂停是指睡眠期间呼吸暂时停止或无呼吸。临床上在呼吸暂停发作时可见血压显著升高。本病例对照研究的目的是检验睡眠呼吸暂停综合征作为非关节炎性前部缺血性视神经病变（NAION）的危险因素。
对19例NAION患者（9例男性和10例女性）和31例年龄及性别匹配的对照参与者（18例男性和13例女性）进行阻塞性睡眠呼吸暂停综合征（OSAS）评估。进行了整夜多导睡眠图检查，并比较了NAION患者和对照组中OSAS的比例。还评估了NAION的其他危险因素，如高血压、糖尿病、高脂血症、缺血性心脏病和吸烟情况。采用卡方检验和独立样本t检验进行统计分析。
19例NAION患者中，18例（95%）患有OSAS，对照组中有13例（41.9%）患有OSAS。与对照组相比，NAION患者中OSAS的发生率显著更高（p<0.001）。NAION患者的平均呼吸紊乱指数（RDI）为37.65次/小时，标准差=37.61次/小时，对照组为15.05次/小时，标准差=11.97次/小时（p=0.018）。NAION患者中糖尿病和高血压的发生率显著高于对照组。
基于本研究结果，似乎NAION与OSAS之间存在关联。
