Hagenbeek Fiona A, Kluft Cornelis, Hankemeier Thomas, Bartels Meike, Draisma Harmen H M, Middeldorp Christel M, Berger Ruud, Noto Antonio, Lussu Milena, Pool René, Fanos Vassilios, Boomsma Dorret I
Department of Biological Psychology, VU Amsterdam, Amsterdam, The Netherlands.
EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):719-32. doi: 10.1002/ajmg.b.32435. Epub 2016 Feb 23.
Human aggression encompasses a wide range of behaviors and is related to many psychiatric disorders. We introduce the different classification systems of aggression and related disorders as a basis for discussing biochemical biomarkers and then present an overview of studies in humans (published between 1990 and 2015) that reported statistically significant associations of biochemical biomarkers with aggression, DSM-IV disorders involving aggression, and their subtypes. The markers are of different types, including inflammation markers, neurotransmitters, lipoproteins, and hormones from various classes. Most studies focused on only a limited portfolio of biomarkers, frequently a specific class only. When integrating the data, it is clear that compounds from several biological pathways have been found to be associated with aggressive behavior, indicating complexity and the need for a broad approach. In the second part of the paper, using examples from the aggression literature and psychiatric metabolomics studies, we argue that a better understanding of aggression would benefit from a more holistic approach such as provided by metabolomics. © 2016 Wiley Periodicals, Inc.
人类攻击性涵盖广泛的行为，且与许多精神疾病相关。我们介绍攻击性及相关障碍的不同分类系统，以此作为讨论生化生物标志物的基础，然后概述在人类中（1990年至2015年间发表）的研究，这些研究报告了生化生物标志物与攻击性、涉及攻击性的《精神疾病诊断与统计手册》第四版（DSM-IV）障碍及其亚型之间具有统计学意义的关联。这些标志物有不同类型，包括炎症标志物、神经递质、脂蛋白以及各类激素。大多数研究仅聚焦于有限的一组生物标志物，通常仅关注某一特定类别。在整合数据时，很明显已发现来自多个生物途径的化合物与攻击性行为相关，这表明情况复杂，需要采用广泛的方法。在本文的第二部分，我们通过引用攻击性文献和精神科代谢组学研究的实例，认为采用代谢组学提供的更全面方法将有助于更好地理解攻击性。© 2016威利期刊公司
