Zhang Hua, Shyaula Sajan L, Li Jing-Ya, Li Jia, Yue Jian-Min
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
Nepal Academy of Science and Technology , Khumaltar, Lalitpur, G.P.O. Box 3323, Kathmandu 44700, Nepal.
Org Lett. 2016 Mar 4;18(5):1202-5. doi: 10.1021/acs.orglett.6b00362. Epub 2016 Feb 25.
Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β.
对尼泊尔产喜马拉叶虎皮楠生物碱成分的化学研究得到了两种具有前所未有的碳骨架的新化合物——喜马拉叶虎皮楠碱A（1）和喜马拉叶虎皮楠碱B（2）。这两种生物碱的结构已通过光谱方法，特别是二维核磁共振数据分析得以表征。喜马拉叶虎皮楠碱B（2）对两种激酶，即蛋白酪氨酸磷酸酶1B（PTP1B）和核因子κB抑制激酶β（IKK-β）表现出微弱的抑制活性。
