Schlundt Claudia, Schell Hanna, Goodman Stuart B, Vunjak-Novakovic Gordana, Duda Georg N, Schmidt-Bleek Katharina
Julius Wolff Institut and Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
J Exp Orthop. 2015 Dec;2(1):1. doi: 10.1186/s40634-014-0017-6. Epub 2015 Feb 7.
We summarize research approaches and findings on bone healing and regeneration that were presented at a workshop at the 60th annual meeting of the Orthopedic Research Society (ORS) in New Orleans in 2014. The workshop was designed to discuss the role of inflammation in bone regeneration in the context of fundamental biology, and to develop therapeutic strategies that involve immune modulation. Delayed or non-healing of bone is a major clinical problem, with around 10% of fracture patients suffering from unsatisfying healing outcomes. Inflammation is traditionally seen as a defense mechanism, but was recently found essential in supporting and modulating regenerative cascades. In bone healing, macrophages and T- and B-cells interact with progenitor cells, bone forming osteoblasts and remodeling osteoclasts. Among the cells of the innate immunity, macrophages are promising candidates for targets in immune-modulatory interventions that would overcome complications in bone healing and bone-related diseases. Among the cells of the adaptive immune system, CD8+ T cells have been shown to have a negative impact on bone fracture healing outcome, whereas regulatory T cells could be promising candidates that have a positive, modulating effect on bone fracture healing. This workshop addressed recent advances and key challenges in this exciting interdisciplinary research field.
我们总结了2014年在新奥尔良举行的骨科研究学会（ORS）第60届年会上的一个研讨会上所展示的关于骨愈合与再生的研究方法及成果。该研讨会旨在探讨炎症在基础生物学背景下对骨再生的作用，并制定涉及免疫调节的治疗策略。骨延迟愈合或不愈合是一个主要的临床问题，约10%的骨折患者愈合效果不佳。传统上炎症被视为一种防御机制，但最近发现它在支持和调节再生级联反应中至关重要。在骨愈合过程中，巨噬细胞、T细胞和B细胞与祖细胞、形成骨的成骨细胞以及重塑骨的破骨细胞相互作用。在固有免疫系统的细胞中，巨噬细胞是免疫调节干预的有希望的靶点，这些干预将克服骨愈合和骨相关疾病中的并发症。在适应性免疫系统的细胞中，CD8 + T细胞已被证明对骨折愈合结果有负面影响，而调节性T细胞可能是对骨折愈合有积极调节作用的有希望的候选细胞。本次研讨会探讨了这个令人兴奋的跨学科研究领域的最新进展和关键挑战。
